|AM251||opioid in rats via experiment (n=122)||Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization||Apr 2012|
Ingestion Method: intravenous|
Action Pathway: CRF,CB1
The CB1 receptor antagonist, AM251, blocked CRF-induced reinstatement of cocaine seeking but was without effect on footshock- or cocaine-induced reinstatement of cocaine seeking
|AM251||diabetes in mice||Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice.||Feb 2008|
Ingestion Method: 6 mg/kg|
These data indicate that sub-chronic antagonism of the cannabinoid CB1 receptor by daily treatment with AM251 counters aspects of the hyperphagia-related impairment of ob/ob mouse metabolism. Such effects seem predominantly mediated by restriction of energy intake.