Cannabis and AM251
Browse the latest research linking medical marijuana / medicinal cannabis and AM251.
Action: CB1 inverse agonist
(cannabinoid (synthetic)) AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists [Wikipedia]
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Compounds Topics Title Date
AM251 opioid in rats via experiment (n=122) Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization Apr 2012
Ingestion Method: intravenous
Action Pathway: CRF,CB1
The CB1 receptor antagonist, AM251, blocked CRF-induced reinstatement of cocaine seeking but was without effect on footshock- or cocaine-induced reinstatement of cocaine seeking
AM251 diabetes in mice Antidiabetic effects of sub-chronic administration of the cannabinoid receptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice. Feb 2008
Ingestion Method: 6 mg/kg
These data indicate that sub-chronic antagonism of the cannabinoid CB1 receptor by daily treatment with AM251 counters aspects of the hyperphagia-related impairment of ob/ob mouse metabolism. Such effects seem predominantly mediated by restriction of energy intake.