Cannabis and AM6545
Browse the latest research linking medical marijuana / medicinal cannabis and AM6545.
Action: CB1 silent antagonist
(cannabinoid (synthetic)) AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity. [Wikipedia]
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Compounds Topics Title Date
WIN55,AM6545 weight loss,obesity in mice via experiment Cannabinoid CB1 Receptors Inhibit Gut-Brain Satiation Signaling in Diet-Induced Obesity Mar 2019
Action Pathway: CB1
Collectively, these results provide evidence that hyperphagia associated with DIO is driven by a mechanism that includes CB1R-mediated inhibition of gut-brain satiation signaling.
AM6545 obesity in mice Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity Aug 2010
Action Pathway: CB1
Here we have demonstrated that a CB1R neutral antagonist largely restricted to the periphery does not affect behavioral responses mediated by CB1R in the brains of mice with genetic or diet-induced obesity, but it does cause weight-independent improvements in glucose homeostasis, fatty liver, and plasma lipid profile
AM6545 obesity,appetite supress in vitro A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents Oct 2010
Peripherally active, cannabinoid receptor antagonists with limited brain penetration may be useful agents for the treatment of obesity and its complications.
AM6545 obesity,appetite supress in rats via experiment THE NOVEL CANNABINOID CB1 ANTAGONIST AM6545 SUPPRESSES FOOD INTAKE AND FOOD-REINFORCED BEHAVIOR Aug 2010
Ingestion Method: 16mg/kg
AM6545 also produced a strong suppression of the intake of high carbohydrate and high fat diets in the same dose range, but only produced a mild suppression of lab chow intake at the highest dose (16.0 mg/kg). Although AM6545 did not affect food handling, it did reduce time spent feeding and feeding rate. Taken together, these results suggest that AM6545 is a compound that warrants further study as a potential appetite suppressant drug.