Cannabis and adolescent use
Browse the latest research linking medical marijuana / medicinal cannabis and adolescent use.
The effects of youth and adolescent use of cannabis and cannabinoids
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Compounds Topics Title Date
THC adolescent use in rats Adolescent exposure to delta-9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons Oct 2018
Overall, adolescent THC exposure altered the morphological and transcriptional trajectory of PFC pyramidal neurons, which could enhance vulnerability to psychiatric disorders.
cannabis adolescent use in mice Adolescent delta-9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-kappa-B-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood Jun 2019
The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of delta-9-tetrahydrocannabinol (delta-9-THC), a cannabis constituent and partial agonist of brain cannabinoid receptor 1
WIN55 adolescent use in mice via placebo trial Behavioral effects of chronic WIN 55,212-2 administration during adolescence and adulthood in mice. May 2019
Ingestion Method: 3.0 mg/kg/day WIN 55,212-2
For the reversal-learning task, there was no difference in errors or omissions to criterion following a reversal in adolescent-exposed mice but adult-exposed mice showed a delay in beginning the reversal, suggesting that adolescents, but not adults, are resilient to this drug. Adult mice given WIN 55,212-2 in adolescence displayed greater impulsivity in the form of preference for smaller-sooner reinforcers over larger-delayed ones in the delay-discounting procedure, but this was seen to a lesser extent with adult-onset exposure.
cannabis adolescent use in humans via study (n=1989) Associations between Adolescent Cannabis Use and Neuropsychological Decline: A Longitudinal Co-Twin Control Study Feb 2018
Negative  Compared with adolescents who did not use cannabis, adolescents who used cannabis had lower IQ in childhood, prior to cannabis initiation, and had lower IQ at age 18, but there was little evidence that cannabis use was associated with IQ decline from age 12-18.