|CBG||appetite boost in rats via placebo trial||Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats||Aug 2016|
Ingestion Method: 30-120 mg/kg, per ora (p.o.)|
CBG produced no adverse effects on any parameter in the neuromotor tolerability test battery. In the feeding assay, 120-240 mg/kg CBG more than doubled total food intake and increased the number of meals consumed, and at 240 mg/kg reduced latency to feed. However, the sizes or durations of individual meals were not significantly increased.
|cannabis||hiv,pain,appetite boost in humans via survey (n=523)||Cannabis Use in HIV for Pain and Other Medical Symptoms||Apr 2005|
|Positive Symptom control using cannabis is widespread in HIV outpatients. A large number of patients reported that cannabis improved symptom control.|
|THC||appetite boost in humans via study||A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.||Nov 2011|
|These findings are consistent with modulation of appetite hormones mediated through endogenous cannabinoid receptors, independent of glucose metabolism.|
|CBG||appetite boost in rats via experiment (n=16)||A cannabigerol-rich Cannabis sativa extract, devoid of d9-tetrahydrocannabinol, elicits hyperphagia in rats.||Jun 2017|
Ingestion Method: 30-240 mg/kg|
Positive The total food intake was increased by 120 and 240 mg/kg CBG-BDS (1.53 and 1.36 g, respectively, vs. 0.56 g in vehicle-treated animals). Latency to feeding onset was dose dependently decreased at all doses, and 120 and 240 mg/kg doses increased both the number of meals consumed and the cumulative size of the first two meals.
|THC,CBD||appetite boost in humans via placebo trial (n=289)||Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group.||Jun 2006|
Ingestion Method: CE (standardized for 2.5 mg THC and 1 mg cannabidiol) or THC (2.5 mg) or PL orally,|
Action Pathway: twice daily for 6 weeks
Neutral CE at the oral dose administered was well tolerated by these patients with CACS. No differences in patients' appetite or QOL were found either between CE, THC, and PL or between CE and THC at the dosages investigated.
|Dronabinol||appetite boost,hiv in humans via trial (n=139)||Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.||Feb 1995|
|Positive Dronabinol was found to be safe and effective for anorexia associated with weight loss in patients with AIDS.|
|Dronabinol||appetite boost,sleep,cancer in humans via placebo trial (n=47/65)||Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial.||Sep 2011|
|Positive THC-treated patients reported improved (P = 0.026) and enhanced (P < 0.001) chemosensory perception and food 'tasted better' (P = 0.04). Premeal appetite (P = 0.05) and proportion of calories consumed as protein increased compared with placebo (P = 0.008). THC-treated patients reported increased quality of sleep (P = 0.025) and relaxation (P = 0.045).|
|Nabilone||appetite boost,lung cancer in humans via placebo trial (n=65)||The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial.||Sep 2018|
Ingestion Method: 0.5 mg/2 weeks followed by 1.0 mg/6 weeks|
Positive Nabilone increased their caloric intake (342-kcal) and had a significantly higher intake of carbohydrates (64 g) compared to patients receiving placebo (p = 0.040). Quality of life also showed significant improvements in patients in the experimental arm of the trial, particularly in role functioning (p = 0.030), emotional functioning (p = 0.018), social functioning (p = 0.036), pain (p = 0.06), and insomnia (p = 0.020).
|THC||appetite boost in humans via placebo trial (n=17)||Effect of acute delta-9-tetrahydrocannabinol administration on subjective and metabolic hormone responses to food stimuli and food intake in healthy humans: a randomized, placebo-controlled study.||Apr 2019|
|Positive THC increased "liking" (P = 0.031) and "wanting" ratings (P = 0.0096) of the high-calorie, but not the low-calorie images, compared with placebo. Participants consumed significantly more milkshake after THC than after placebo during oral intake (P = 0.0005), but not intragastric infusion, of milkshake.|