|CBD,CBG||ovarian cancer in vitro via experiment||Evaluation of the effects of cannabinoids CBD and CBG on human ovarian cancerc ells in vitro||Jan 2019|
Action Pathway: GPR55|
CBD and CBG induced dose-dependent and time-dependent cytotoxic effects on the ovarian cancer cells tested with activity at micromolar concentrations towards the A2780 and A2780/CP70 cancer cells whilst displaying less activity against the non-cancer cells. CBD was the more potent of the two cannabinoids. However, the difference observed was not significant compared to CBG. CBD and CBG in combination with the established chemotherapeutic drug carboplatin showed synergistic effects in the cancer cells but importantly, CBD and CBG did not synergise with carboplatin in the non-cancer ARPE19 cells.