|Pinene||cancer,pancreatic cancer in mice via experiment||Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis||Oct 2012|
Ingestion Method: intraperitoneal|
Intraperitoneal administration of alpha-pinene reduced the pancreatic weight (PW) to body weight (BW) ratio and the serum levels of amylase and lipase. Alpha-pinene treatment also reduced histological damage and myeloperoxidase activity in the pancreas and lungs.
|THC,CBD||cancer,pancreatic cancer in humans via review||Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer.||Jan 2019|
Action Pathway: CB1,CB2,GPR55|
Neutral Cannabinol receptors have been identified in pancreatic cancer with several studies showing in vitro antiproliferative and proapoptotic effects. Cannabinoids may be an effective adjunct for the treatment of pancreatic cancer. Data on the anticancer effectiveness of various cannabinoid formulations, treatment dosing, precise mode of action, and clinical studies are lacking.
|cannabinoids||cancer,pancreatic cancer in vitro||Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.||Jul 2006|
Action Pathway: p8|
Studies conducted with MiaPaCa2 and Panc1 cell lines showed that cannabinoid administration (a) induced apoptosis, (b) increased ceramide levels, and (c) up-regulated mRNA levels of the stress protein p8.