||Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone
Our findings are the first to show that the neuroprotective effect of nerolidol is mediated through its anti-oxidant and anti-inflammatory activities, which strongly supports its therapeutic potential for the treatment of PD.
||Inhibition of Acetylcholinesterase Activity by Bicyclic Monoterpenoids
alpha-pinene and (+)-3-carene were potent inhibitors of AChE.
in humans via review
||Evidence for the use of cannabinoids in Parkinson's disease.
There is increasing understanding of the endocannabinoid system, and the distribution of cannabinoid receptors in basal ganglia structures might suggest potential benefit on parkinsonian symptoms. Concerning clinical research, only one of to date four conducted randomized placebo-controlled trials showed an effect on motor symptoms with alleviation of levodopa-induced dyskinesia. There are a growing number of uncontrolled trials and case reports that suggest beneficial effects of cannabinoids in PD patients.