|anti-inflamatory,pain in mice via placebo trial (n=36)
|Borneol, a Bicyclic Monoterpene Alcohol, Reduces Nociceptive Behavior and Inflammatory Response in Mice
Ingestion Method: 5, 25, and 50 mg/kg
Together, our results suggest that borneol possess significant central and peripheral antinociceptive activity; it has also anti-inflammatory activity. In addition, borneol did not impair motor coordination.
|pain in vitro
|Inhibition of acetylcholine-mediated effects by borneol.
|The inhibitory effect by borneol is more potent than the effect by lidocaine, a commonly used local anesthetic. The data suggest that borneol specifically inhibits the nAChR-mediated effects in a noncompetitive way.
|drug potentiator in mice
|Effect of borneol on the distribution of gastrodin to the brain in mice via oral administration.
|Compared with the administration of gastrodin alone, gastrodin coadministrated with borneol could have been rapidly absorbed from the gastrointestinal tract; the peak time of gastrodin in the plasma became shorter (5-15 vs. 30 min); the bioavailability of gastrodigenin in the brain was increased by 33.6-108.8%; and obvious brain-targeting effect was observed.
|anti-coagulant in vitro
|The antithrombotic effect of borneol related to its anticoagulant property.
|It suggested that the antithrombotic activity of borneol and its action in combined formula for preventing cardiovascular diseases might be due to anticoagulant activity rather than antiplatelet activity.
|anti-fibrosis in mice via model
|Influence of borneol on primary mice oral fibroblasts: a penetration enhancer may be used in oral submucous fibrosis.
Ingestion Method: 18.75 to 300 microg/ml
This study indicates that borneol has anti-fibrosis activity and the mechanism may partly be relevant to its inhibiting effects on fibroblasts mitosis, collagen and TIMP-1 production. It can be safely used as a penetration enhancer for our formula to treat OSF.
|anti-oxidant in vitro
|Borneol alleviates oxidative stress via upregulation of Nrf2 and Bcl-2 in SH-SY5Y cells
|Borneol protected SH-SY5Y cells against Abeta--induced toxicity, exerted an antioxidative effect and suppressed apoptosis. It increases our knowledge about neuroprotective mechanism of borneol, and it is hopeful to be a candidate compound for developing therapeutic drug for the prevention and treatment of AD and other Abeta--related neurodegenerative diseases.
|anti-inflamatory in vitro
|Identification of 1,8-cineole, borneol, camphor, and thujone as anti-inflammatory compounds in a Salvia officinalis L. infusion using human gingival fibroblasts.
Ingestion Method: Salvia officinalis L. infusion
Therefore, the volatile compounds were found to be more effective than rosmarinic acid. 1,8-Cineole, borneol, camphor, and alpha--/beta--thujone chiefly contribute to the anti-inflammatory activity of sage infusion in human gingival fibroblasts.
|drug potentiator in rats
|Improved blood-brain barrier distribution: Effect of borneol on the brain pharmacokinetics of kaempferol in rats by in vivomicrodialysis sampling
|Borneol can enhance the blood brain barrier permeability and improve the transportation of Kaempferol to brain.
|anti-oxidant in vitro
|A new source of natural D-borneol and its characteristic
Ingestion Method: The essential oils from leaves of Mei Pian tree
Antioxidant activities of the refined D-borneol and standard D-borneol were determined by testing their DPPH and hydroxyl radicals scavenging activities and the reducing power. The refined D-borneol and standard D-borneol had the same antioxidant activity.