Welcome to the Cannabis Knowledge Database

Browse our indexed database of cannabis-related medical studies and journal articles by Topic or Compound by using the tabs above.

The index currently contains 602 studies of 59 compounds across 128 topics.

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Topics Class # of Papers Description
Acne condition 1
Addiction condition 14 Cannabis and cannabinoids and the treatment of addiction disorders
Attention Deficit Hyperactive Disorder condition 7
Adolescent Use topic 11 The effects of youth and adolescent use of cannabis and cannabinoids
Alzheimer's Disease condition 11 Alzheimer's disease is a type of dementia that causes problems with memory, thinking and behavior
See also: memory  neuroprotective 
Anti-bacterial property 11 Slows or halts growth of bacteria
Anti-coagulant property 1 Prevents blood clots
See also: stroke 
anti-convulsant property 4
See also: epilepsy 
Anti-fibrosis property 2 Inhibits growth of scar tissue
anti-fungal property 5
Anti-inflamatory property 52 Verdict: Positive with Moderate evidence level
Multiple cannabinoids and terpenes have been shown to releive inflamation.
See also: pain 
anti-microbial property 2
anti-oxidant property 19
anti-psychotic property 4
Anti-viral property 7 Destroys viruses
Anxiety condition 18 Verdict: Positive with Moderate evidence level
Anxiety is an accepted use of medical cannabis in many jurisdictions.
Appetite Boost property 9 Verdict: Positive with Moderate evidence level
Medical cannabis (via THC) is an accepted treatment for chemotherapy and AIDS induced appetite loss
Appetite Supress property 4
Osteoarthritis condition 6
See also: ra 
Asthma condition 2 Verdict: Negative with Moderate evidence level
Autism condition 10 ASD and other social disorders have been linked to imbalances of the endocannabinoid system
Bladder Dysfunction condition 1
Bladder Cancer condition 1
Blood Cancer condition 2
See also: cancer 
High Blood Pressure symptom 1
See also: vasorelaxant 
High Blood Sugar symptom 0
See also: diabetes 
Boost Immune System property 1
Breast Cancer condition 15
Breath-hold Duration topic 2 Verdict: Negative with High evidence level
Holding hits in longer does NOT result in higher or longer intoxication
Cancer condition 95 Verdict: Neutral with Moderate evidence level
While Cannabis is an accepted treatment for several cancer side-effects, direct evidence in humans is lacking. Cannabinoid signalling implicated in vitro in the growth cycles of several tumor types.
Cardiovascular topic 4
Cervical Cancer condition 1
Chemotaxonomy topic 8
Chemotherapy topic 6 Verdict: Positive with High evidence level
Medical Cannabis has been aproved for the treatment of chemotherapy side effects.
See also: nausea 
High Cholesterol symptom 3
Chronic Pain symptom 3
See also: pain 
Colon topic 1
Colon Cancer condition 8
Cannabis Consumption Methods topic 2
Chronic Obstructive Pulmonary Disease condition 2
Crime topic 2 Effects of cannabis legalization on crime rates
Crohn's Disease condition 2
See also: ibd 
Cannabis Use Disorder condition 13
Cultivation topic 4
Depression condition 10
Diabetes condition 26 Verdict: Positive with Low evidence level
Cannabis use appears to have a protective effect with respect to diabetes, although mechanisms are not known.
Duchenne muscular dystrophy condition 1
Driving topic 6 Driving under the influence of cannabis
Drug Potentiator topic 16 Influences or affects the metabolism of another drug
EB condition 1 EB is blistering condition, in which even minor knocks and friction can cause the skin to blister or ulcer.
Elderly topic 2 Considerations for the use of cannabis and cannabinoids by elderly people
Endocannibanoid System topic 1
Entourage Effect topic 7
Epilepsy condition 12
See also: anti-convulsant 
Excercise topic 2 Excercising under the influence of cannabis
Extraction topic 1 Cannabis extraction processes
Fibromyalgia condition 2
Fragile X Syndrome condition 2
Gastroparesis condition 1
Gender Differences topic 2 Differences of Cannabis metabolism or endocannibanoid systems of men and women
Glioma condition 8
See also: cancer 
Graft vs Host Disease condition 4
Headache symptom 5
Heartburn symptom 0
Heroin Addiction condition 1
See also: addiction 
Herpes Virus condition 1
History topic 1 History of Cannabis
Human Immunodeficiency Virus condition 6
See also: appetite boost  pain  neuropathy 
Huntingtons Disease condition 2
Cannabis Hyperemesis Disorder condition 6
Inflamatory Bowel Disease condition 8
See also: crohns 
Insomnia condition 3
Intestinal Health topic 1
Kidney Cancer condition 1
See also: cancer 
Laxative property 1
Leg Ulcuers condition 1
Leukemia condition 5
See also: cancer 
Liver topic 16 Fatty Liver Disease and other liver-released disorders
Lung cancer condition 10
See also: cancer 
Malaria condition 1
Melanoma condition 1
See also: cancer 
Memory topic 2
See also: alzheimers 
Metabolism topic 12
Methamphetamine Addiction condition 2
See also: addiction 
Migraine Headache condition 5
See also: pain  headache 
Multiple Sclerosis condition 8 Verdict: Positive with Moderate evidence level
Medical cannabis has been shown superior to placebo in reducing pain and spasticity in MS patients in human placeo trials.
See also: pain  spasticity 
Nausea symptom 7
Neuropathy symptom 7 Verdict: Positive with Moderate evidence level
Neuropathic Pain
Neuroprotective property 8
See also: parkinsons 
Nicotine Addiction condition 2 Use of cannabinoids for Cigarette/Tobbaco sessasion
See also: addiction 
Obesity condition 9
See also: weight loss 
Obsessive Compusive Disorder condition 1
Opioid Addiction condition 16
Oral cancer condition 2
See also: cancer 
Ovarian Cancer condition 1
See also: cancer 
Pain symptom 50 Verdict: Positive with Moderate evidence level
While not an ideal first-line treatment, cannabis and syntheic cannabinoids have been shown as effective anaglesics, especially against neuropathic pain.
See also: anti-inflamatory  neuropathy 
Pancreatic Cancer condition 4
See also: cancer 
Parkinsons Disease condition 5
Chronic Pelvic Pain condition 1
Pharmacology topic 2 Cannabis and Cannabinoids Pharmacology
Placebo Effects topic 1
Pregnancy topic 9 Verdict: Negative with Medium evidence level
Cannabis use during pregnancy has been linked to low birth weight and increased rate of miscarriage.
Prostate Cancer condition 9
Post-Traumatic Stress Disorder condition 11
Rheumatoid Arthritis condition 4
See also: arthritis 
Renal Cell Carcinoma condition 1
Rett Syndrome condition 1
Safety topic 14
Schitzophrenia condition 2
Second-Hand Smoke topic 5
Sedative property 16 Sleeping aids
Sexual Health topic 8 Effects of Cannabis and Cannabinoids on sexual health
Side Effects topic 2
Skin Cancer condition 4
See also: cancer 
Sleep symptom 7
See also: sedative 
Spasticity symptom 4 Verdict: Positive with High evidence level
Cannabis is an accepted medical use for the treatment of spasticity.
Stomach Cancer condition 1
See also: cancer 
Stress symptom 3
Stroke condition 3
See also: cardiovascular  anti-coagulant 
Traumatic Brain Injury condition 1
Testicular Cancer condition 2
Toxicity topic 2
Vaccine Injury condition 1
Vasorelaxant property 3 Lowers blood pressure
Veterinary Use topic 1 Veterinary uses of cannabinoids (cats and dogs)
Weight Loss topic 9
See also: obesity 
Tourette Syndrome condition 7 Verdict: Positive with Medium evidence level
Tics due to Tourette Syndrome respond to cannabis preparations
Bone Health topic 1
Compond Class (Boil Pt) # of Papers Description
cannabinoids 53 Catch-all for cannabinoid subjects and studies
cannabis 173 Catch-all for medical cannabis topics and studies
Cannabichromene (CBC) cannabinoid (220℃) 7 Cannabichromene (CBC), also called cannabichrome, cannanbichromene, pentylcannabichromene or cannabinochromene, is one of the 120 cannabinoids found in the Cannabis plant.  [Link]
Cannabidiol (CBD) cannabinoid (180℃) 115 The second most common phytocannibanoid  [Link]
Cannabidivarin (CBDV) cannabinoid (165℃) 6 Cannabidivarin (CBDV) is a non-psychoactive cannabinoid found in Cannabis. It is a homolog of cannabidiol (CBD), with the side-chain shortened by two methylene bridges (CH2 units)  [Link]
Cannabigerol (CBG) cannabinoid (52℃) 11 Cannabigerol is the non-acidic form of cannabigerolic acid, the parent molecule from which other cannabinoids are synthesized. Cannabigerol is a minor constituent of cannabis  [Link]
Cannabinol (CBN) cannabinoid (185℃) 7 Cannabinol is a slightly psycoative, more sedative oxidation by-product of THC  [Link]
Tetrahydrocannabinol (THC) cannabinoid (157℃) 65 The principal psychoactive constituent of cannabis  [Link]
Tetrahydrocannabivarin (THCV) cannabinoid (220℃) 6 Cannibanoid with more intense, shorter-lasting effects then THC  [Link]
Abnormal Cannabidiol (Abn-CBD) cannabinoid (synthetic) 1 Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects.  [Link]
AM251 cannabinoid (synthetic) 3 AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists  [Link]
AM6545 cannabinoid (synthetic) 4 AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity.  [Link]
CR701 cannabinoid (synthetic) 0 Caras most advanced CB compound, CR701, is in preclinical development.  [Link]
Dronabinol cannabinoid (synthetic) 5 Dronabinol, sold as trade names Marinol and Syndros, is an appetite stimulant, antiemetic, and sleep apnea reliever.  [Link]
H2CBD cannabinoid (synthetic) 1 8,9-dihydrocannibidiol (H2CBD) is a fully synthetic analogue of CBD that is prepared from inexpensive, non-cannabis derived precursors.
HU-210 cannabinoid (synthetic) 2 HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.  [Link]
HU-308 cannabinoid (synthetic) 1 HU-308 is a drug that acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1  [Link]
HU-331 cannabinoid (synthetic) 2 HU-331 is a quinone anticarcinogenic drug synthesized from cannabidiol, a cannabinoid in the Cannabis sativa plant.  [Link]
JWH-015 cannabinoid (synthetic) 5 JWH-015 is a chemical from the naphthoylindole family that acts as a subtype-selective cannabinoid agonist.  [Link]
JWH-018 cannabinoid (synthetic) 1 JWH-018 (or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC).  [Link]
JWH-133 cannabinoid (synthetic) 5 JWH-133 is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors.  [Link]
JZL184 cannabinoid (synthetic) 1 JZL184 is an irreversible inhibitor for monoacylglycerol lipase (MAGL), the primary enzyme responsible for degrading the endocannabinoid 2-arachidonoylglycerol (2-AG).  [Link]
Nabilone cannabinoid (synthetic) 9 Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain.  [Link]
O-1602 cannabinoid (synthetic) 2 O-1602 does not bind to the classical cannabinoid receptors CB1 or CB2 with any significant affinity, but instead is an agonist at several other receptors which appear to be related to the cannabinoid receptors, particularly GPR18 and GPR55.  [Link]
O-1966 cannabinoid (synthetic) 1
PF3845 cannabinoid (synthetic) 1 PF-3845 is a selective inhibitor of fatty acid amide hydrolase, which results in increased levels of anandamide and thus cannabinoid receptor-based effects.  [Link]
Rimonabant cannabinoid (synthetic) 10 Rimonabant (also known as SR141716; trade names Acomplia, Zimulti)[3] is an anorectic antiobesity drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in the United States.  [Link]
WIN-55,212-2 (WIN55) cannabinoid (synthetic) 11 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure  [Link]
WWL70 cannabinoid (synthetic) 1 WWL70 is a selective inhibitor of alpha-/beta--hydrolase domain-containing 6 (ABHD6), a serine hydrolase that acts as an alternative hydrolase of the endocannabinoid 2-arachidonoylglycerol (2-AG).  [Link]
Zygel (ZYN002) cannabinoid (synthetic) 1 CONNECT-FX is a clinical trial evaluating ZYN002, an experimental transdermally delivered CBD gel, as a treatment for some of the common and debilitating behaviors in patients with FXS  [Link]
Nabiximols (Sativex) concentrate 7 Nabiximols is a specific extract of Cannabis (1:1) that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms of multiple sclerosis; it was developed by the UK company GW Pharmaceuticals.  [Link]
Epidiolex concentrate 3 High-CBD cannabis extract aproved for the treament of seizures  [Link]
2-Arachidonoylglycerol (2AG) endocannabinoid 2 2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor.  [Link]
Anandamide (ANA) endocannabinoid 5 Anandamide (also known as N-arachidonoylethanolamine or AEA), is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential o-6 polyunsaturated fatty acid.  [Link]
Cannflavin flavonoid 3 Cannflavins are a group of chemical compounds found in Cannabis sativa. Chemically, they are prenylflavonoids and are unrelated to THC and other cannabinoids.  [Link]
Satipharm CBD Gelpell (PTL101) isolate 1 The PTL101 drug beads utilise a proprietary formulation developed through Satipharms Gelpell-CBD(TM) product technology, which contain organically derived, highly purified CBD  [Link]
AM404 metabolite 1 AM404, also known as N-arachidonoylaminophenol,[1] is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action[2] and anticonvulsant effects.  [Link]
11-Nor-9-carboxy-THC (THC-COOH) metabolite 2 11-Nor-9-carboxy-delta-9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC), which is formed in the body after cannabis is consumed.  [Link]
11-Hydroxy-THC (THC-OH) metabolite 1 11-Hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after decarboxylated cannabis is consumed  [Link]
Rho-Cymene (Cymene) monoterpene (177℃) 7 Rho-Cymene has a musty scent and is found naturally in thyme, cumin and other spices.  [Link]

Flavors: Spicy
Also in: coriander, eucalyptus, marjoram
Eucalyptol monoterpene (177℃) 1 Eucalyptol comprises up to 90% of the essential oil of some species of the generic product eucalyptus oil,[1] hence the common name of the compound.  [Link]

Flavors: Mint, Spicy
Also in: Wormwood, Rosemary, Sage
Geraniol monoterpene (230℃) 7 An acyclic monoterpene alcohol with a sweet rose-like aroma.  [Link]

Flavors: Flower
Also in: roses, lemon grass, blueberries, lemons peels, and carrots,
D-Limonene (Limonene) monoterpene (176℃) 21 Limonene is found in the peels and oils of many citrus fruits, including lemon, orange, mandarin, lime, and grapefruit.  [Link]

Flavors: Citrus
Also in: Citrus Rinds, Juniper, Peppermint
Linalool monoterpene (198℃) 25 Linalool is a monoterpene compound, commonly found as major component of essential oils of several aromatic species, many of which are used traditionally as sedatives.  [Link]

Flavors: Floral
Also in: Lavender, Citrus, Laurel, Birch, Rosewood
Beta-Myrcene (Myrcene) monoterpene (167℃) 11 Most commonly found terpene in cannabis.  [Link]

Flavors: Musky
Also in: Mango, Thyme, Citrus, Lemongrass, Bay Leaves
Ocimene monoterpene (55-65℃) 4 Ocimene is a cannabis terpene carrying a sweet, herbaceous, and earthy aroma with hints of citrus.  [Link]

Flavors: Fruity
Also in: mint, parsley, pepper, basil, mangoes, orchids
Alpha-Pinene (Pinene) monoterpene (155℃) 15 Alpha-pinene has a woody and earthy aroma, with clear cedarwood and pine tones  [Link]

Flavors: Pine, Herb
Also in: Pine Needles, Sage, Eucalyptus, Conifers
Terpineol monoterpene (219℃) 3 Terpineol has a pleasant odor similar to lilac and is a common ingredient in perfumes, cosmetics, and flavors.  [Link]

Flavors: Sweet, Lilac
Also in: Cajuput, Pine, Petitgrain
Alpha-Bisabolol (Bisabolol) sesquiterpene (153℃) 9 Bisabolol is a cannabis terpene boasting a delicately sweet and floral aroma with hints of citrus and spice.  [Link]

Flavors: Sweet
Also in: chamomile flower, candeia tree
Beta-Caryophyllene (Caryophyllene) sesquiterpene (130℃) 21 The terpene that's also a cannibanoid, capable of interacting with CB2 endoctrine receptors.  [Link]

Flavors: Woody
Also in: Peper, Cloves, Hops, Basil, Oregano
Guaiol sesquiterpene (92℃) 4 Unlike most cannabis terpenes, guaiol is classified as a sesquiterpenoid alcohol.  [Link]

Flavors: Piney
Also in: Guaiacum tree
Alpha-Humulene (Humulene) sesquiterpene (106℃) 7 Humulene is an isomer of caryophyllene that's been shown to interact directly with the endocrtine system  [Link]

Flavors: Woody
Also in: Hops, Coreander
Borneol terpene (213℃) 9 Borneol is a bicyclic organic compound and a terpene derivative.  [Link]

Flavors: Minty
Also in: Camphor, rosemary, mint plants
Eugenol terpene (254℃) 2 Eugenol is an allyl chain-substituted guaiacol, a member of the allylbenzene class of chemical compounds.  [Link]
Also in: Cloves, Nutmeg, Dill, Ginger
Trans-Nerolidol (Nerolidol) terpene (122℃) 7 Nerolidol is a terpene that is also known as peruviol, and has two isomers and is a sesquiterpene which means it is more stable than other terpenes.  [Link]

Flavors: Woody
Also in: Ginger, Jasmne, Lavender
Alpha/Beta-Phellandrene (Phellandrene) terpene (171℃) 4 Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and similar chemical properties.  [Link]

Flavors: Mint, Citrus
Also in: Allspice, Eucalyptus
Gamma-Terpinene (Terpinene) monoterpene (174℃) 3 The terpinenes are a group of isomeric hydrocarbons that are classified as monoterpenes.  [Link]

Flavors: Spicy, Cloves
Also in: Cumin, Mint
Delta-Terpinene (Terpinolene) monoterpene (186℃) 6 Terpinolene is the terpene partly responsible for the woody, piney smell cannabis can often have.  [Link]

Flavors: Woody
Also in: Tea Tree, Conifers, apple, sage, cumin, rosemary, lilac
SEDDS-CBD concentrate 1 A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means.  [Link]