Welcome to the Cannabis Knowledge Database

Browse our indexed database of cannabis-related medical studies and journal articles by Topic or Compound by using the tabs above.

The index currently contains 600 studies of 59 compounds across 128 topics.

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Topics Class # of Papers Description
Acne condition 1
Addiction condition 14 Cannabis and cannabinoids and the treatment of addiction disorders
Attention Deficit Hyperactive Disorder condition 7
Adolescent Use topic 11 The effects of youth and adolescent use of cannabis and cannabinoids
Alzheimer's Disease condition 11 Alzheimer's disease is a type of dementia that causes problems with memory, thinking and behavior
See also: memory  neuroprotective 
Anti-bacterial property 11 Slows or halts growth of bacteria
Anti-coagulant property 1 Prevents blood clots
See also: stroke 
anti-convulsant property 4
See also: epilepsy 
Anti-fibrosis property 2 Inhibits growth of scar tissue
anti-fungal property 5
Anti-inflamatory property 52 Verdict: Positive with Moderate evidence level
Multiple cannabinoids and terpenes have been shown to releive inflamation.
See also: pain 
anti-microbial property 2
anti-oxidant property 19
anti-psychotic property 4
Anti-viral property 7 Destroys viruses
Anxiety condition 18 Verdict: Positive with Moderate evidence level
Anxiety is an accepted use of medical cannabis in many jurisdictions.
Appetite Boost property 9 Verdict: Positive with Moderate evidence level
Medical cannabis (via THC) is an accepted treatment for chemotherapy and AIDS induced appetite loss
Appetite Supress property 4
Osteoarthritis condition 6
See also: ra 
Asthma condition 2 Verdict: Negative with Moderate evidence level
Autism condition 10 ASD and other social disorders have been linked to imbalances of the endocannabinoid system
Bladder Dysfunction condition 1
Bladder Cancer condition 1
Blood Cancer condition 2
See also: cancer 
High Blood Pressure symptom 1
See also: vasorelaxant 
High Blood Sugar symptom 0
See also: diabetes 
Boost Immune System property 1
Breast Cancer condition 15
Breath-hold Duration topic 2 Verdict: Negative with High evidence level
Holding hits in longer does NOT result in higher or longer intoxication
Cancer condition 94 Verdict: Neutral with Moderate evidence level
While Cannabis is an accepted treatment for several cancer side-effects, direct evidence in humans is lacking. Cannabinoid signalling implicated in vitro in the growth cycles of several tumor types.
Cardiovascular topic 4
Cervical Cancer condition 1
Chemotaxonomy topic 8
Chemotherapy topic 6 Verdict: Positive with High evidence level
Medical Cannabis has been aproved for the treatment of chemotherapy side effects.
See also: nausea 
High Cholesterol symptom 3
Chronic Pain symptom 3
See also: pain 
Colon topic 1
Colon Cancer condition 8
Cannabis Consumption Methods topic 2
Chronic Obstructive Pulmonary Disease condition 2
Crime topic 2 Effects of cannabis legalization on crime rates
Crohn's Disease condition 2
See also: ibd 
Cannabis Use Disorder condition 13
Cultivation topic 4
Depression condition 10
Diabetes condition 26 Verdict: Positive with Low evidence level
Cannabis use appears to have a protective effect with respect to diabetes, although mechanisms are not known.
Duchenne muscular dystrophy condition 1
Driving topic 6 Driving under the influence of cannabis
Drug Potentiator topic 16 Influences or affects the metabolism of another drug
EB condition 1 EB is blistering condition, in which even minor knocks and friction can cause the skin to blister or ulcer.
Elderly topic 2 Considerations for the use of cannabis and cannabinoids by elderly people
Endocannibanoid System topic 1
Entourage Effect topic 7
Epilepsy condition 12
See also: anti-convulsant 
Excercise topic 2 Excercising under the influence of cannabis
Extraction topic 1 Cannabis extraction processes
Fibromyalgia condition 2
Fragile X Syndrome condition 2
Gastroparesis condition 1
Gender Differences topic 2 Differences of Cannabis metabolism or endocannibanoid systems of men and women
Glioma condition 8
See also: cancer 
Graft vs Host Disease condition 3
Headache symptom 5
Heartburn symptom 0
Heroin Addiction condition 1
See also: addiction 
Herpes Virus condition 1
History topic 1 History of Cannabis
Human Immunodeficiency Virus condition 6
See also: appetite boost  pain  neuropathy 
Huntingtons Disease condition 2
Cannabis Hyperemesis Disorder condition 6
Inflamatory Bowel Disease condition 8
See also: crohns 
Insomnia condition 3
Intestinal Health topic 1
Kidney Cancer condition 1
See also: cancer 
Laxative property 1
Leg Ulcuers condition 1
Leukemia condition 5
See also: cancer 
Liver topic 16 Fatty Liver Disease and other liver-released disorders
Lung cancer condition 10
See also: cancer 
Malaria condition 1
Melanoma condition 1
See also: cancer 
Memory topic 2
See also: alzheimers 
Metabolism topic 12
Methamphetamine Addiction condition 2
See also: addiction 
Migraine Headache condition 5
See also: pain  headache 
Multiple Sclerosis condition 8 Verdict: Positive with Moderate evidence level
Medical cannabis has been shown superior to placebo in reducing pain and spasticity in MS patients in human placeo trials.
See also: pain  spasticity 
Nausea symptom 7
Neuropathy symptom 7 Verdict: Positive with Moderate evidence level
Neuropathic Pain
Neuroprotective property 8
See also: parkinsons 
Nicotine Addiction condition 2 Use of cannabinoids for Cigarette/Tobbaco sessasion
See also: addiction 
Obesity condition 9
See also: weight loss 
Obsessive Compusive Disorder condition 1
Opioid Addiction condition 16
Oral cancer condition 2
See also: cancer 
Ovarian Cancer condition 1
See also: cancer 
Pain symptom 50 Verdict: Positive with Moderate evidence level
While not an ideal first-line treatment, cannabis and syntheic cannabinoids have been shown as effective anaglesics, especially against neuropathic pain.
See also: anti-inflamatory  neuropathy 
Pancreatic Cancer condition 4
See also: cancer 
Parkinsons Disease condition 5
Chronic Pelvic Pain condition 1
Pharmacology topic 2 Cannabis and Cannabinoids Pharmacology
Placebo Effects topic 1
Pregnancy topic 9 Verdict: Negative with Medium evidence level
Cannabis use during pregnancy has been linked to low birth weight and increased rate of miscarriage.
Prostate Cancer condition 9
Post-Traumatic Stress Disorder condition 11
Rheumatoid Arthritis condition 4
See also: arthritis 
Renal Cell Carcinoma condition 1
Rett Syndrome condition 1
Safety topic 14
Schitzophrenia condition 2
Second-Hand Smoke topic 5
Sedative property 16 Sleeping aids
Sexual Health topic 8 Effects of Cannabis and Cannabinoids on sexual health
Side Effects topic 2
Skin Cancer condition 4
See also: cancer 
Sleep symptom 7
See also: sedative 
Spasticity symptom 4 Verdict: Positive with High evidence level
Cannabis is an accepted medical use for the treatment of spasticity.
Stomach Cancer condition 1
See also: cancer 
Stress symptom 3
Stroke condition 3
See also: cardiovascular  anti-coagulant 
Traumatic Brain Injury condition 1
Testicular Cancer condition 2
Toxicity topic 2
Vaccine Injury condition 1
Vasorelaxant property 3 Lowers blood pressure
Veterinary Use topic 1 Veterinary uses of cannabinoids (cats and dogs)
Weight Loss topic 9
See also: obesity 
Tourette Syndrome condition 7 Verdict: Positive with Medium evidence level
Tics due to Tourette Syndrome respond to cannabis preparations
Bone Health topic 1
Compond Class (Boil Pt) # of Papers Description
cannabinoids 53 Catch-all for cannabinoid subjects and studies
cannabis 173 Catch-all for medical cannabis topics and studies
Cannabichromene (CBC) cannabinoid (220℃) 7 Cannabichromene (CBC), also called cannabichrome, cannanbichromene, pentylcannabichromene or cannabinochromene, is one of the 120 cannabinoids found in the Cannabis plant.  [Link]
Cannabidiol (CBD) cannabinoid (180℃) 115 The second most common phytocannibanoid  [Link]
Cannabidivarin (CBDV) cannabinoid (165℃) 6 Cannabidivarin (CBDV) is a non-psychoactive cannabinoid found in Cannabis. It is a homolog of cannabidiol (CBD), with the side-chain shortened by two methylene bridges (CH2 units)  [Link]
Cannabigerol (CBG) cannabinoid (52℃) 11 Cannabigerol is the non-acidic form of cannabigerolic acid, the parent molecule from which other cannabinoids are synthesized. Cannabigerol is a minor constituent of cannabis  [Link]
Cannabinol (CBN) cannabinoid (185℃) 7 Cannabinol is a slightly psycoative, more sedative oxidation by-product of THC  [Link]
Tetrahydrocannabinol (THC) cannabinoid (157℃) 65 The principal psychoactive constituent of cannabis  [Link]
Tetrahydrocannabivarin (THCV) cannabinoid (220℃) 6 Cannibanoid with more intense, shorter-lasting effects then THC  [Link]
Abnormal Cannabidiol (Abn-CBD) cannabinoid (synthetic) 1 Abnormal cannabidiol (Abn-CBD) is a synthetic regioisomer of cannabidiol, which unlike most other cannabinoids produces vasodilator effects, lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing any psychoactive effects.  [Link]
AM251 cannabinoid (synthetic) 3 AM-251 is an inverse agonist at the CB1 cannabinoid receptor. AM-251 is structurally very close to SR141716A (rimonabant); both are biarylpyrazole cannabinoid receptor antagonists  [Link]
AM6545 cannabinoid (synthetic) 4 AM-6545 is a drug which acts as a peripherally selective silent antagonist for the CB1 receptor, and was developed for the treatment of obesity.  [Link]
CR701 cannabinoid (synthetic) 0 Caras most advanced CB compound, CR701, is in preclinical development.  [Link]
Dronabinol cannabinoid (synthetic) 5 Dronabinol, sold as trade names Marinol and Syndros, is an appetite stimulant, antiemetic, and sleep apnea reliever.  [Link]
H2CBD cannabinoid (synthetic) 1
HU-210 cannabinoid (synthetic) 2 HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.  [Link]
HU-308 cannabinoid (synthetic) 1 HU-308 is a drug that acts as a cannabinoid agonist. It is highly selective for the CB2 receptor subtype, with a selectivity of over 5000x for CB2 vs CB1  [Link]
HU-331 cannabinoid (synthetic) 1
JWH-015 cannabinoid (synthetic) 5 JWH-015 is a chemical from the naphthoylindole family that acts as a subtype-selective cannabinoid agonist.  [Link]
JWH-018 cannabinoid (synthetic) 1 JWH-018 (or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC).  [Link]
JWH-133 cannabinoid (synthetic) 5 JWH-133 is a potent selective CB2 receptor agonist with a Ki of 3.4nM and selectivity of around 200x for CB2 over CB1 receptors.  [Link]
JZL184 cannabinoid (synthetic) 1
Nabilone cannabinoid (synthetic) 9 Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain.  [Link]
O-1602 cannabinoid (synthetic) 1
O-1966 cannabinoid (synthetic) 1
PF3845 cannabinoid (synthetic) 1
Rimonabant cannabinoid (synthetic) 10 Rimonabant (also known as SR141716; trade names Acomplia, Zimulti)[3] is an anorectic antiobesity drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in the United States.  [Link]
WIN-55,212-2 (WIN55) cannabinoid (synthetic) 11 WIN 55,212-2 is a chemical described as an aminoalkylindole derivative, which produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure  [Link]
WWL70 cannabinoid (synthetic) 1
Zygel (ZYN002) cannabinoid (synthetic) 1 CONNECT-FX is a clinical trial evaluating ZYN002, an experimental transdermally delivered CBD gel, as a treatment for some of the common and debilitating behaviors in patients with FXS  [Link]
Nabiximols (Sativex) concenrate 7 Nabiximols is a specific extract of Cannabis (1:1) that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms of multiple sclerosis; it was developed by the UK company GW Pharmaceuticals.  [Link]
Epidiolex concentrate 3 High-CBD cannabis extract aproved for the treament of seizures  [Link]
2-Arachidonoylglycerol (2AG) endocannabinoid 2 2-Arachidonoylglycerol (2-AG) is an endocannabinoid, an endogenous agonist of the CB1 receptor and the primary endogenous ligand for the CB2 receptor.  [Link]
Anandamide (ANA) endocannabinoid 5 Anandamide (also known as N-arachidonoylethanolamine or AEA), is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential ?-6 polyunsaturated fatty acid.  [Link]
Cannflavin flavonoid 3 Cannflavins are a group of chemical compounds found in Cannabis sativa. Chemically, they are prenylflavonoids and are unrelated to THC and other cannabinoids.  [Link]
Satipharm CBD Gelpell (PTL101) isolate 1 The PTL101 drug beads utilise a proprietary formulation developed through Satipharms Gelpell-CBD(TM) product technology, which contain organically derived, highly purified CBD  [Link]
AM404 metabolite 1 AM404, also known as N-arachidonoylaminophenol,[1] is an active metabolite of paracetamol (acetaminophen), responsible for all or part of its analgesic action[2] and anticonvulsant effects.  [Link]
11-Nor-9-carboxy-THC (THC-COOH) metabolite 2 11-Nor-9-carboxy-delta-9-tetrahydrocannabinol (11-COOH-THC or THC-COOH), often referred to as 11-nor-9-carboxy-THC or THC-11-oic acid, is the main secondary metabolite of tetrahydrocannabinol (THC), which is formed in the body after cannabis is consumed.  [Link]
11-Hydroxy-THC (THC-OH) metabolite 1 11-Hydroxy-delta-9-tetrahydrocannabinol (11-OH-THC), usually referred to as 11-hydroxy-THC, is the main active metabolite of tetrahydrocannabinol (THC), which is formed in the body after decarboxylated cannabis is consumed  [Link]
Rho-Cymene (Cymene) monoterpene (177℃) 7 Rho-Cymene has a musty scent and is found naturally in thyme, cumin and other spices.  [Link]

Flavors: Spicy
Also in: coriander, eucalyptus, marjoram
Eucalyptol monoterpene (177℃) 1 Eucalyptol comprises up to 90% of the essential oil of some species of the generic product eucalyptus oil,[1] hence the common name of the compound.  [Link]

Flavors: Mint, Spicy
Also in: Wormwood, Rosemary, Sage
Geraniol monoterpene (230℃) 7 An acyclic monoterpene alcohol with a sweet rose-like aroma.  [Link]

Flavors: Flower
Also in: roses, lemon grass, blueberries, lemons peels, and carrots,
D-Limonene (Limonene) monoterpene (176℃) 21 Limonene is found in the peels and oils of many citrus fruits, including lemon, orange, mandarin, lime, and grapefruit.  [Link]

Flavors: Citrus
Also in: Citrus Rinds, Juniper, Peppermint
Linalool monoterpene (198℃) 25 Linalool is a monoterpene compound, commonly found as major component of essential oils of several aromatic species, many of which are used traditionally as sedatives.  [Link]

Flavors: Floral
Also in: Lavender, Citrus, Laurel, Birch, Rosewood
Beta-Myrcene (Myrcene) monoterpene (167℃) 11 Most commonly found terpene in cannabis.  [Link]

Flavors: Musky
Also in: Mango, Thyme, Citrus, Lemongrass, Bay Leaves
Ocimene monoterpene (55-65℃) 4 Ocimene is a cannabis terpene carrying a sweet, herbaceous, and earthy aroma with hints of citrus.  [Link]

Flavors: Fruity
Also in: mint, parsley, pepper, basil, mangoes, orchids
Alpha-Pinene (Pinene) monoterpene (155℃) 15 Alpha-pinene has a woody and earthy aroma, with clear cedarwood and pine tones  [Link]

Flavors: Pine, Herb
Also in: Pine Needles, Sage, Eucalyptus, Conifers
Terpineol monoterpene (219℃) 3 Terpineol has a pleasant odor similar to lilac and is a common ingredient in perfumes, cosmetics, and flavors.  [Link]

Flavors: Sweet, Lilac
Also in: Cajuput, Pine, Petitgrain
Alpha-Bisabolol (Bisabolol) sesquiterpene (153℃) 9 Bisabolol is a cannabis terpene boasting a delicately sweet and floral aroma with hints of citrus and spice.  [Link]

Flavors: Sweet
Also in: chamomile flower, candeia tree
Beta-Caryophyllene (Caryophyllene) sesquiterpene (130℃) 21 The terpene that's also a cannibanoid, capable of interacting with CB2 endoctrine receptors.  [Link]

Flavors: Woody
Also in: Peper, Cloves, Hops, Basil, Oregano
Guaiol sesquiterpene (92℃) 4 Unlike most cannabis terpenes, guaiol is classified as a sesquiterpenoid alcohol.  [Link]

Flavors: Piney
Also in: Guaiacum tree
Alpha-Humulene (Humulene) sesquiterpene (106℃) 7 Humulene is an isomer of caryophyllene that's been shown to interact directly with the endocrtine system  [Link]

Flavors: Woody
Also in: Hops, Coreander
Borneol terpene (213℃) 9 Borneol is a bicyclic organic compound and a terpene derivative.  [Link]

Flavors: Minty
Also in: Camphor, rosemary, mint plants
Eugenol terpene (254℃) 2  [Link]
Also in: Cloves, Nutmeg, Dill, Ginger
Trans-Nerolidol (Nerolidol) terpene (122℃) 7 Nerolidol is a terpene that is also known as peruviol, and has two isomers and is a sesquiterpene which means it is more stable than other terpenes.  [Link]

Flavors: Woody
Also in: Ginger, Jasmne, Lavender
Alpha/Beta-Phellandrene (Phellandrene) terpene (171℃) 4 Phellandrene is the name for a pair of organic compounds that have a similar molecular structure and similar chemical properties.  [Link]

Flavors: Mint, Citrus
Also in: Allspice, Eucalyptus
Terpinene terpene (174℃) 3  [Link]
Terpinolene terpene (186℃) 6 Terpinolene is the terpene partly responsible for the woody, piney smell cannabis can often have.  [Link]

Flavors: Woody
Also in: Tea Tree, Conifers, apple, sage, cumin, rosemary, lilac
SEDDS-CBD concentrate 1 A self-microemulsifying drug delivery system (SMEDDS) is a drug delivery system that uses a microemulsion achieved by chemical rather than mechanical means.  [Link]