| CBC |
anti-inflamatory
in vitro |
The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis |
May 2013 |
|
Cannabichromene exerts anti-inflammatory actions in activated macrophages - with tonic CB1 cannabinoid signalling being negatively coupled to this effect - and ameliorates experimental murine colitis.
|
| CBD,CBG,CBC |
cancer,breast cancer
in vitro |
Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. |
May 2006 |
|
Results obtained in a panel of tumor cell lines clearly indicate that, of the five natural compounds tested, cannabidiol is the most potent inhibitor of cancer cell growth (IC(50) between 6.0 and 10.6 microM), with significantly lower potency in noncancer cells. The cannabidiol-rich extract was equipotent to cannabidiol, whereas cannabigerol and cannabichromene followed in the rank of potency.
|
| CBN,CBD,CBC,THC,CBN |
anti-bacterial
in vitro |
anti-bacterial cannabinoids from Cannabis sativa: a structure-activity study. |
August 2008 |
|
All five major cannabinoids (cannabidiol (1b), cannabichromene (2), cannabigerol (3b), Delta (9)-tetrahydrocannabinol (4b), and cannabinol (5)) showed potent activity against a variety of methicillin-resistant Staphylococcus aureus (MRSA) strains of current clinical relevance
|
| CBC |
anti-inflamatory
in mice |
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice. |
Jun 2012 |
|
CBC selectively reduces inflammation-induced hypermotility in vivo in a manner that is not dependent on cannabinoid receptors or TRPA1.
|
| CBD,CBN,CBC |
pain
in rats |
Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain |
May 2019 |
|
These results suggest that peripheral application of these non-psychoactive cannabinoids may provide analgesic relief for chronic muscle pain disorders such as temporomandibular disorders and fibromyalgia without central side effects.
|
| CBC,THC |
pain
in mice |
Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol. |
1983 |
|
CBC had a weak analgetic action in mice; THC had a moderate and lengthy effect, which was potentiated at 2 hr by concurrent CBC. Both CBC (10-75 mg/kg, i.p.) and THC (20 mg/kg) reduced motility of mice, the THC equalling the highest dose of CBC.
|
| CBC |
anti-inflamatory
in vitro,mice |
Anti-inflammatory properties of cannabichromene |
Jun 1980 |
|
CBC was tested in vivo using the rat paw edema test and in vitro using the erythrocyte membrane stabilization assay. CBC was as effective as phenylbutazone (PBZ) at equivalent doses.
|