Cannabis and Caryophyllene
Browse the latest research linking medical marijuana / medicinal cannabis and Beta-Caryophyllene (Caryophyllene) (a sesquiterpene)

Boiling/Vape Point: 130℃
Action: CB2 agonist
Flavors: Woody
Also in: Peper, Cloves, Hops, Basil, Oregano
The terpene that's also a cannibanoid, capable of interacting with CB2 endoctrine receptors. [Wikipedia]
Click on a study title below to open a new tab with full article, or click on a compound to see it's full list of research.
Compounds Topics Title Date
Caryophyllene anti-inflamatory in vitro Beta-caryophyllene is a dietary cannabinoid. Jul 2008
Ingestion Method: 5mg/kg
Action Pathway: CB2
BCP (500 nM) inhibits lipopolysaccharide (LPS)-induced proinflammatory cytokine expression in peripheral blood and attenuates LPS-stimulated Erk1/2 and JNK1/2 phosphorylation in monocytes. Furthermore, peroral (E)-BCP at 5 mg/kg strongly reduces the carrageenan-induced inflammatory response in wild-type mice but not in mice lacking CB(2) receptors, providing evidence that this natural product exerts cannabimimetic effects in vivo.
Caryophyllene anti-inflamatory,ibd in mice via experiment Beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARg pathway Mar 2011
Ingestion Method: 12.5, 25, or 50 mg/kg, p.o.
Action Pathway: CB2,PPARg
These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARg pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease.
Myrcene,Caryophyllene anxiety in humans via experiment (n=5) Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects. Jan 2018
These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativasuggesting a neuromodular activity in cases of stress, depression, and anxiety.
THC,cannabis,Myrcene,Caryophyllene pain,headache in humans via survey (n=2032) Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort May 2018
Positive  Hybrid strains were preferred in ID Migraine(TM), headache, and most pain groups, with OG Shark, a high THC (delta-9-tetrahydrocannabinol)/THCA (tetrahydrocannabinolic acid), low CBD (cannabidiol)/CBDA (cannabidiolic acid), strain with predominant terpenes beta--caryophyllene and beta--myrcene, most preferred in the headache and ID Migraine(TM) groups
Humulene,Pinene,Caryophyllene anti-bacterial in vitro Composition and anti-bacterial activity of Abies balsamea essential oil. May 2006
Ingestion Method: essential oil of Abies balsamea (balsam fir)
However, three constituents of the essential oil were active against S. aureus: alpha-pinene, beta-caryophyllene (0.4%) and alpha-humulene (0.2%) with MIC values of 13.6 microg/mL, 5.1 microg/mL and 2.6 microg/mL, respectively.
Caryophyllene,Humulene anti-microbial in vitro Caryophyllene-rich rhizome oil of Zingiber nimmonii from South India: Chemical characterization and antimicrobial activity. Feb 2006
Ingestion Method: Volatile oil from the rhizomes of Zingiber nimmonii (J. Graham) Dalzell
The oil showed significant inhibitory activity against the fungi, Candida glabrata, C. albicans and Aspergillus niger and the bacteria Bacillus subtilis and Pseudomonas aeruginosa.
Caryophyllene,Humulene drug potentiator in vitro Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel. Dec 2007
Moreover, beta-caryophyllene potentiated the anticancer activity of paclitaxel on MCF-7, DLD-1 and L-929 cell lines. The highest potentiating effect was obtained in DLD-1 cells treated with paclitaxel combined with 10 microg mL(-1) beta-caryophyllene, which increased the paclitaxel activity about 10-fold.
Caryophyllene anti-inflamatory in vitro Anti-inflammatory activity of essential oil from leaves of Myrciaria tenella and Calycorectes sellowianus. Apr 2010
Ingestion Method: M. tenella oil
However, in the systemic treatment with the essential oils (50 mg/kg p.o.) only the M. tenella oil was able to significantly reduce the carrageenan-induced paw edema with a similar effect to that observed for indomethacin (10 mg/kg), the positive control.
Caryophyllene anti-fibrosis,anti-oxidant in vitro The anti-oxidant effect of Beta-caryophyllene protects rat liver from carbon tetrachloride-induced fibrosis by inhibiting hepatic stellate cell activation Feb 2013
Ingestion Method: 1 and 10 um
CAR, a sesquiterpene present in numerous plants and foods, is as a natural antioxidant that reduces carbon tetrachloride-mediated liver fibrosis and inhibits hepatic cell activation.
Caryophyllene pain in mice via experiment Involvement of peripheral cannabinoid and opioid receptors in Beta-caryophyllene-induced antinociception May 2013
Action Pathway: CB2
The present results demonstrate that antinociception produced by BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid beta--endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain.
Caryophyllene anti-inflamatory,pain in mice via model The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Apr 2014
Action Pathway: CB2
In a neuropathic pain model the chronic oral administration of BCP attenuated thermal hyperalgesia and mechanical allodynia, and reduced spinal neuroinflammation. Importantly, we found no signs of tolerance to the anti-hyperalgesic effects of BCP after prolonged treatment.
Caryophyllene depression,anxiety in mice Beta-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice Aug 2014
Ingestion Method: 50mg/kg
Taken together, these preclinical results suggest that CB2 receptors may provide alternative therapeutic targets for the treatment of anxiety and depression. The possibility that BCP may ameliorate the symptoms of these mood disorders offers exciting prospects for future studies.
Caryophyllene diabetes in rats Beta-Caryophyllene, a natural sesquiterpene, modulates carbohydrate metabolism in streptozotocin-induced diabetic rats. Oct 2014
Ingestion Method: 200 mg/kg
BCP at a dose of 200mg/kg b.w. exerted significant antidiabetic effects than other two doses (100 and 400mg/kg b.w.). We conclude that administration of BCP has beneficial effects in glucose homeostasis in diabetic rats.
Caryophyllene,Myrcene arthritis,anti-inflamatory in vitro Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis Mar 2015
These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation.
Caryophyllene anti-oxidant,cancer,colon cancer in vitro The Anticancer, anti-oxidant and Antimicrobial Properties of the Sesquiterpene Beta-Caryophyllene from the Essential Oil of Aquilaria crassna Jun 2015
beta--caryophyllene demonstrated potent inhibition against clonogenicity, migration, invasion and spheroid formation in colon cancer cells. These results prompt us to state that beta--caryophyllene is the active principle responsible for the selective anticancer and antimicrobial activities of A. crassnia.
Caryophyllene anti-inflamatory in vitro Anti-inflammatory and anti-edematogenic action of the Croton campestris A. St.-Hil (Euphorbiaceae) essential oil and the compound beta--caryophyllene in in vivo models. Mar 2018
This study supports the hypothesis that beta--caryophyllene, in association with other constituents present in the EOCC such as 1,8-cineole, contributed to the anti-inflammatory effect observed, in addition to suggesting that one of the mechanisms of action probably involves the inhibition of cytokines with the involvement of the arachidonic acid and histamine pathways.
Caryophyllene epilepsy in mice via experiment Pharmacological characterization of the cannabinoid receptor 2 agonist, beta--caryophyllene on seizure models in mice. Apr 2018
Action Pathway: CB2
Our results suggest that the CB2 receptor agonists might be clinically useful as an adjunct treatment against seizure spread and status epilepticus and concomitant oxidative stress, neurotoxicity and cognitive impairments.
Guaiol,Caryophyllene cancer,lung cancer in vitro via experiment Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells. Dec 2018
alpha--Guaiene, (-)-guaiol and beta--caryophyllene are responsible for most of the cytotoxic activity of BSE against these two cancer cell lines. Since BSE possesses significant cytotoxicity and anti-metastatic activity on A549 and H661 cells, it may serve as a potential target for the treatment of lung cancer.
Caryophyllene diabetes,pain,depression in mice via experiment Beta-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice Mar 2019
Ingestion Method: oral 10 mg/kg/60 mL
Our data using an orally chronic BCP administration in the STZ challenged mice to suggest that glycemia, diabetes-related NP, and depressive-like behavior could be prevented/reduced by dietary BCP.
Caryophyllene memory in mice via experiment The cannabinoid receptor 2 agonist, beta--caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice Mar 2019
Aged mice showed deficits in working memory and higher levels of IL-23, both of which were reversed by BCP treatment. BCP appears to reverse age-associated impairments in memory and modulates cytokine production.
Caryophyllene anti-inflamatory in rats via experiment Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Oct 1996
Thus, beta-caryophyllene elicited anti-inflammatory effects without any indication of gastric mucosal damage typical of non-steroidal anti-inflammatory agents. Furthermore, this compound manifested cytoprotective effects, rendering the two-dimensional efficacious beta-caryophyllene to be a clinically safe and potentially useful agent.