|laxative via review
|Pubchem - Guaiol
|Used by herbalists as a laxative; diuretic.
|cancer,lung cancer in mice via experiment
|(-)-Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer
Action Pathway: RAD51
The following mechanism studies show that (-)-Guaiol is involved in cell autophagy to regulate the expression of RAD51, leading to double-strand breaks triggered cell apoptosis.
|The essential oil from the fruits of the Brazilian spice Xylopia sericea A. St.-Hil. presents expressive in-vitro anti-bacterial and anti-oxidant activity.
Ingestion Method: Xylopia sericea fruits (OXS)
OXS presented a significant antioxidant activity and also a high bacteriostatic effect against Staphylococcus aureus, Enterobacter cloacae, Bacillus cereus and Klebsiella pneumoniae.
|cancer,lung cancer in vitro via experiment
|Bulnesia sarmientoi Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells.
|alpha--Guaiene, (-)-guaiol and beta--caryophyllene are responsible for most of the cytotoxic activity of BSE against these two cancer cell lines. Since BSE possesses significant cytotoxicity and anti-metastatic activity on A549 and H661 cells, it may serve as a potential target for the treatment of lung cancer.