|Humulene||anti-inflamatory in mice via experiment||Preventive and therapeutic anti-inflammatory properties of the sesquiterpene Alpha-humulene in experimental airways allergic inflammation||Oct 2009|
Ingestion Method: 1 mg?mL-1, by aerosol|
alpha--Humulene, given either orally or by aerosol, exhibited marked anti-inflammatory properties in a murine model of airways allergic inflammation, an effect that seemed to be mediated via reduction of inflammatory mediators, adhesion molecule expression and transcription factors activation.
|Humulene||cancer in vitro||Antitumor activity of balsam fir oil: production of reactive oxygen species induced by alpha-humulene as possible mechanism of action||May 2003|
|Balsam fir oil and alpha-humulene induced a dose- and time-dependent decrease in cellular GSH content and an increase in ROS production. These results suggest that GSH depletion and ROS production may be implicated in the cytotoxicity of alpha-humulene and balsam fir oil.|
|Humulene,Pinene,Caryophyllene||anti-bacterial in vitro||Composition and anti-bacterial activity of Abies balsamea essential oil.||May 2006|
Ingestion Method: essential oil of Abies balsamea (balsam fir)|
However, three constituents of the essential oil were active against S. aureus: alpha-pinene, beta-caryophyllene (0.4%) and alpha-humulene (0.2%) with MIC values of 13.6 microg/mL, 5.1 microg/mL and 2.6 microg/mL, respectively.
|Caryophyllene,Humulene||anti-microbial in vitro||Caryophyllene-rich rhizome oil of Zingiber nimmonii from South India: Chemical characterization and antimicrobial activity.||Feb 2006|
Ingestion Method: Volatile oil from the rhizomes of Zingiber nimmonii (J. Graham) Dalzell|
The oil showed significant inhibitory activity against the fungi, Candida glabrata, C. albicans and Aspergillus niger and the bacteria Bacillus subtilis and Pseudomonas aeruginosa.
|Humulene||anti-inflamatory in mice||Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea||Aug 2007|
|The anti-inflammatory effects of alpha-humulene and (-)-trans-caryophyllene were comparable to those observed in dexamethasone-treated animals, used as positive control drug.|
|Caryophyllene,Humulene||drug potentiator in vitro||Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel.||Dec 2007|
|Moreover, beta-caryophyllene potentiated the anticancer activity of paclitaxel on MCF-7, DLD-1 and L-929 cell lines. The highest potentiating effect was obtained in DLD-1 cells treated with paclitaxel combined with 10 microg mL(-1) beta-caryophyllene, which increased the paclitaxel activity about 10-fold.|
|Humulene||anti-inflamatory,pain in mice||Pharmacokinetics and tissue distribution of the sesquiterpene alpha-humulene in mice||Nov 2008|
|Taken together, these findings further contribute to an explanation of the topical and systemic anti-inflammatory and antinociceptive properties previously reported for the essential oil and for alpha-humulene obtained from Cordia verbenacea, they also provide support for the clinical studies conducted with the phytomedicine Acheflan.|