Cannabis and JWH-018
Browse the latest research linking medical marijuana / medicinal cannabis and JWH-018 (a cannabinoid (synthetic))

Action: CB1 and CB2 agonist
JWH-018 (or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannabinol (THC). [Wikipedia]
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Compounds Topics Title Date
JWH-018 metabolism,safety in humans via experiment (n=17) Neurocognition and Subjective Experience Following Acute Doses of the Synthetic Cannabinoid JWH-018: Responders Versus Nonresponders Aug 2019
Ingestion Method: 2-6mg inhaled
Serum concentrations of JWH-018 were significantly higher in the responders. Overall, JWH-018 increased heart rate within the first hour and significantly impaired critical tracking and memory performance. Responders to JWH-018 performed more poorly in tests measuring reaction time and showed increased levels of confusion, amnesia, dissociation, derealization, and depersonalization and increased drug liking after JWH-018.