Limonene
Limonene is found in the peels and oils of many citrus fruits, including lemon, orange, mandarin, lime, and grapefruit.
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Uses Title Date
anti-oxidant
D-limonene exhibits anti-inflammatory and anti-oxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. Apr 2017
anti-oxidant
Role of oxygen free radicals in cancer development. 1996
cancer (breast)
D-Limonene: safety and clinical applications. Sept 2007
cancer (stomach)
[D-limonene induces apoptosis of gastric cancer cells]. July 2003
boost immune
Modulation of immune responses in mice by d-limonene. 1987
stress
Anti-stress effects of d-limonene and its metabolite perillyl alcohol 2014
anxiety
Anxiolytic-like activity and GC-MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants Jan 2013
pain (physical)
Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, Alpha-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model. July 2015
pain (muscle)
D-limonene exhibits superior antihyperalgesic effects in a Beta-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice. Sept 2007
Heartburn
D-Limonene: safety and clinical applications Sept 2007
blood pressure
Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet and L-NAME-treated rats. Feb 2012
cholesterol
blood sugar
Preventive and ameliorating effects of citrus D-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity. Sept 2013
anti-inflamatory (colon)
Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans. July 2013
anti-inflamatory (intenstine)
D-limonene exhibits anti-inflammatory and anti-oxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. April 2017
depression
Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, Alpha-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model. July 2015
anti-inflamatory
cancer
D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis. Aug 2012
cancer
Chemoprevention and therapy of cancer by d-limonene 1994
depression
Biological Effects of Myristica fragrans Mar 2009
anti-oxidant
Chemical composition, antioxidant activity and antimicrobial activity of essential oil from Citrus aurantium L zest against some pathogenic microorganisms. Jan 2019
anti-oxidant
cancer
diabetes
anti-viral
Limonene: Aroma of innovation in health and disease. Mar 2018
cholesterol
Antioxidative and Cholesterol-Lowering Effects of Lemon Essential Oil in Hypercholesterolemia-Induced Rabbits. Mar 2018
anti-bacterial
Mechanism of Bacterial Inactivation by (+)-Limonene and Its Potential Use in Food Preservation Combined Processes Feb 2013
anti-inflamatory
Differential Effects of Limonene on Inflammation via Activation of A2A and A2B Adenosine Receptors in Asthma Apr 2019