| Compounds | Topics | Title | Date |
|---|---|---|---|
| Limonene | anti-inflamatory,asthma in mice via experiment | Differential Effects of Limonene on Inflammation via Activation of A2A and A2B Adenosine Receptors in Asthma | Apr 2019 |
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Action Pathway: A2AAR,A2BAR We have shown that limonene induces bronchodilation and lowers inflammation via A2A receptor activation (FASEB J April 2017 31:820.1) in a mouse model of asthma. | |||
| Limonene | anti-bacterial in vitro | Mechanism of Bacterial Inactivation by (+)-Limonene and Its Potential Use in Food Preservation Combined Processes | Feb 2013 |
| The study of the mechanism of bacterial inactivation by (+)-limonene showed that the lethality of this compound was higher at pH 4.0 than at neutral pH | |||
| Limonene | pain,anti-inflamatory in mice | Biological effects of Myristica fragrans (nutmeg) extract. | Jun 1999 |
| The chloroform extract of nutmeg has been evaluated for antiinflammatory, analgesic and antithrombotic activities in rodents. The extract inhibited the carrageenan-induced rat paw oedema, produced a reduction in writhings induced by acetic acid in mice and offered protection against thrombosis induced by ADP/adrenaline mixture in mice. | |||
| Limonene | cancer,stomach cancer in vitro | [D-limonene induces apoptosis of gastric cancer cells]. | July 2003 |
| D-limonene could induce the formation of apoptotic bodies in a dose- and time-dependent manner. The expression of bcl-2 protein decreased and p53 protein increased in BGC-823 cells treated with D-limonene, compared with the control cells. | |||
| Myrcene,Limonene | anti-inflamatory in mice | Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. | Aug 2003 |
| The oils, when administered orally, were able to inhibit the LPS-induced inflammation including cell migration; with a similar effect being observed for pure limonene. | |||
| Limonene | safety in humans | D-Limonene: safety and clinical applications. | Sept 2007 |
| Subsequent studies have determined how these tumors occur and established that d-limonene does not pose a mutagenic, carcinogenic, or nephrotoxic risk to humans. In humans, d-limonene has demonstrated low toxicity after single and repeated dosing for up to one year. | |||
| Limonene | diabetes,vasorelaxant in rats | Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet and L-NAME-treated rats. | Feb 2012 |
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Ingestion Method: oral Dietary supplementation with d-limonene reversed the HFD and L-NAME-induced changes and restored pathological alteration of liver and pancreas. | |||
| Limonene | anti-inflamatory,cancer in mice | D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis. | Aug 2012 |
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Ingestion Method: 50-100mg/kg We found that D-limonene (50 and 100 mg/kg body weight) treatments to the mouse skin significantly reduced the TPA-induced (a) edema and hyperplasia (p < 0.001); (b) expression of cyclooxygenase-2; (c) ornithine decarboxylase activity (p < 0.001); and (d) [(3)H] thymidine incorporation into DNA (p < 0.001) | |||
| Limonene | anxiety in mice via experiment | Anxiolytic-like activity and GC-MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants | Jan 2013 |
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Ingestion Method: inhaled 1% These data suggest possible connections between the volatility of (+)-limonene and its anxiolytic-like effect on the parameters evaluated in the elevated plus maze test. The data indicate that (+)-limonene could be used in aromatherapy as an antianxiety agent. | |||
| Limonene | anti-inflamatory,colon in rats via experiment | Oral administration of d-limonene controls inflammation in rat colitis and displays anti-inflammatory properties as diet supplementation in humans. | July 2013 |
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Ingestion Method: 10mg/kg oral In conclusion, d-Limonene indeed demonstrates significant anti-inflammatory effects both in vivo and in vitro. Protective effects on the epithelial barrier and decreased cytokines are involved, suggesting a beneficial role of d-Limonene as diet supplement in reducing inflammation. | |||
| Limonene | cholesterol,diabetes in mice | Preventive and ameliorating effects of citrus D-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity. | Sept 2013 |
| Our data suggest that the intake of d-limonene may benefit patients with dyslipidemia and hyperglycemia and is a potential dietary supplement for preventing and ameliorating metabolic disorders. | |||
| Limonene | stress in mice | Anti-stress effects of d-limonene and its metabolite perillyl alcohol | Apr 2014 |
| In addition to its anti-inflammatory effects, a beneficial role as an anti-stress substance could thus be claimed for d-limonene used as a dietary supplement. | |||
| Limonene,Phellandrene | pain,depression in rats via experiment | Antihyperalgesic and antidepressive actions of (R)-(+)-limonene, Alpha-phellandrene, and essential oil from Schinus terebinthifolius fruits in a neuropathic pain model. | July 2015 |
| Together, the results of the present work show that essential oil of S. terebinthifolius and compounds present in this oil, including (R)-(+)-limonene and alpha--phellandrene, exhibit antihyperalgesic effects against mechanical hyperalgesia, and are antidepressive, | |||
| Limonene | anti-oxidant,anti-inflamatory,intenstine in rats | D-limonene exhibits anti-inflammatory and anti-oxidant properties in an ulcerative colitis rat model via regulation of iNOS, COX-2, PGE2 and ERK signaling pathways. | Apr 2017 |
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Action Pathway: iNOS, COX-2, PGE2, TGF-beta- In conclusion, D-limonene reduced MMP-2 and -9 mRNA expression levels via regulation of the iNOS, COX-2, PGE2, TGF-beta- and ERK1/2 signaling pathways in a UC rat model, indicating its potential antioxidant and anti-inflammatory properties. | |||
| Limonene | pain in mice via experiment | D-limonene exhibits superior antihyperalgesic effects in a Beta-cyclodextrin-complexed form in chronic musculoskeletal pain reducing Fos protein expression on spinal cord in mice. | Sept 2007 |
| After induction of hyperalgesia, the oral administration of LIM-beta-CD (50mg/kg) significantly increased the paw withdrawal threshold compared to uncomplexed limonene. Fos immunofluorescence showed that both compounds significantly decreased the number of Fos-positive cells in the dorsal horn. In nociceptive tests, FLU was able to reverse the antinociceptive effect of LIM-beta-CD | |||
| Limonene | anti-oxidant,cancer,diabetes,anti-viral via review | Limonene: Aroma of innovation in health and disease. | Mar 2018 |
| The therapeutic effects of limonene have been extensively studied, proving anti-inflammatory, antioxidant, antinociceptive, anticancer, antidiabetic, antihyperalgesic, antiviral, and gastroprotective effects, among other beneficial effects in health. | |||
| Limonene | cholesterol,anti-oxidant in rabbits via experiment | Antioxidative and Cholesterol-Lowering Effects of Lemon Essential Oil in Hypercholesterolemia-Induced Rabbits. | Mar 2018 |
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Ingestion Method: lemon essential oil (LEO) In conclusion, LEO had beneficial effects on hypercholesterolemia due to its antioxidative and cholesterol lowering effects. | |||
| Linalool,Limonene | cardiovascular via review | The use of terpenes and derivatives as a new perspective for cardiovascular disease treatment: a patent review (2008-2018). | Dec 2018 |
| Several studies have shown the application of terpenes, such as carvacrol, linalool, and limonene in many pharmaceutical and medicinal fields, including cardiovascular disorders, the leading cause of death worldwide. | |||
| Limonene | anti-oxidant in vitro via experiment | Chemical composition, antioxidant activity and antimicrobial activity of essential oil from Citrus aurantium L zest against some pathogenic microorganisms. | Jan 2019 |
| Gram-positive bacteria were more sensitive to the oil (inhibition zones being between 9 and 12.5 mm) and the minimum inhibitory concentration was more than 600 ppm; Gram-negative bacteria were less sensitive. The obtained essential oil displayed promising results for its application as a biopreservative agent. | |||
| Limonene | boost immune in mice via experiment | Modulation of immune responses in mice by d-limonene. | 1987 |
| Mice treated with d-limonene prior to KLH priming produced significant increased antibody responses. | |||
| Limonene | cancer in rats via article | Chemoprevention and therapy of cancer by d-limonene | 1994 |
| The naturally occurring monoterpene d-limonene has chemopreventive and chemotherapeutic activity against many rodent solid tumor types. The chemopreventive activity of limonene during initiation can be attributed to the induction of phase I and phase II enzymes, with resulting carcinogen detoxification. | |||