|sedative,pain via review
|Lavender and the Nervous System
|Several animal and human investigations suggest anxiolytic, mood stabilizer, sedative, analgesic, and anticonvulsive and neuroprotective properties for lavender.
|anti-convulsant in vitro
|anticonvulsant properties of linalool in glutamate-related seizure models.
|The data indicate that linalool modulates glutamate activation expression in vitro (competitive antagonism of L-[3H]glutamate binding) and in vivo (delayed NMDA convulsions and blockage of QUIN convulsions).
|anxiety,insomnia,epilepsy in mice
|Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L.
|The results obtained with EOP in the anxiety model, and with EOP, HF and DF in the sedation model, are in accord with the ethnopharmacological use of Citrus aurantium L., which could be useful in primary medical care, after toxicological investigation.
|anti-inflamatory,pain in mice
|(-)-Linalool produces antinociception in two experimental models of pain.
Ingestion Method: 25, 50, 75 and 100 mg/kg
The more pronounced effect of (-)-linalool on the writhing test with respect to the hot plate test is consistent with the observation that (-)-linalool possesses anti-inflammatory activity.
|anti-inflamatory in rats
|anti-inflammatory activity of linalool and linalyl acetate constituents of essential oils.
Ingestion Method: essential oil from Citrus aurantium L.
The results obtained indicate that linalool and the corresponding acetate play a major role in the anti-inflammatory activity displayed by the essential oils containing them, and provide further evidence suggesting that linalool and linalyl acetate-producing species are potentially anti-inflammatory agents.
|anti-fungal in vitro
|Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil.
|All tea tree oil components, except beta-myrcene, had antifungal activity. The lack of activity reported for some components by microdilution may be due to these components becoming absorbed into the polystyrene of the microtitre tray.
|pain in humans via placebo trial (n=54)
|Treatment with lavender aromatherapy in the post-anesthesia care unit reduces opioid requirements of morbidly obese patients undergoing laparoscopic adjustable gastric banding.
Ingestion Method: inhaled lavender oil
Positive Significantly more patients in the Placebo group (PL) required analgesics for postoperative pain (22/27, 82%) than patients in the Lavender group (LAV) (12/26, 46%) (P = .007). Moreover, the LAV patients required significantly less morphine postoperatively than PL patients: 2.38 mg vs 4.26 mg, respectively (P = .04)
|sedative in mice
|Inhaled linalool-induced sedation in mice.
Ingestion Method: 1-3% inhaled
The 1% and 3% linalool increased (p<0.01) pentobarbital sleeping time and reduced (p<0.01) body temperature. The 3% linalool decreased (p<0.01) locomotion. Motor coordination was not affected. Hence, linalool inhaled for 1h seems to induce sedation without significant impairment in motor abilities, a side effect shared by most psycholeptic drugs.
|anti-oxidant in vitro
|Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells
Ingestion Method: 0.05-1.5 mg/plate and 0.01-1.0 microg/ml
The results indicate that linalool, eucalyptol and myrcene have substantial protective effect against oxidant induced genotoxicity, which is predominately mediated by their radical scavenging activity.
|pain in mice
|The antinociceptive effect of (-)-linalool in models of chronic inflammatory and neuropathic hypersensitivity in mice.
Ingestion Method: 50 or 200 mg/kg injection
The article adds information about antinociceptive properties of (-)-linalool in chronic inflammatory and neuropathic hypersensitivity. It also indicates that (-)-linalool might be potentially interesting in the development of new clinically relevant drugs for the management of persistent pain.
|anxiety in mice via experiment
|Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models.
Ingestion Method: linalool oxide (0.65%, 1.25%, 2.5% and 5.0% w/w)
Thus, inhaled linalool oxide was found to have anxiolytic properties in both animal models, without causing any motor deficit. These results suggest that inhalation of linalool oxide may be a useful means of counteracting anxiety.
|depression in mice via experiment
|antidepressant activity of Litsea glaucescens essential oil: Identification of Beta-pinene and linalool as active principles
Ingestion Method: 100 and 300 mg/Kg.
L. glaucescens essential oil showed antidepressant activity, beta--pinene and linalool were identified as its active principles. These results support the use of L. glaucescens in Mexican Traditional Medicine for the treatment of sadness.
|vasorelaxant in rats via experiment
|Cardiovascular effects induced by linalool in normotensive and hypertensive rats.
Ingestion Method: 200 mg/kg BW; oral (v.o.)
In conclusion, these results demonstrate that linalool reduces blood pressure probably due to a direct effect on the vascular smooth muscle leading to vasodilation.
|anti-inflamatory in mice
|Linalool and linalool complexed in Beta-cyclodextrin produce anti-hyperalgesic activity and increase Fos protein expression in animal model for fibromyalgia.
Ingestion Method: 25 mg/kg, p.o.
LIN or LIN-CD produced a significant reduction (p < 0.001) of mechanical hyperalgesia on chronic non-inflammatory muscle pain model, which remained for 24 h only in LIN-CD, and these compounds significantly (p < 0.05) activated neurons of the locus coeruleus, nucleus raphe magnus, and periaqueductal gray areas.
|depression in mice
|Linalool and Beta-pinene exert their antidepressant-like activity through the monoaminergic pathway.
|Our results indicate that linalool and beta--pinene produce an antidepressant-like effect through interaction with the monoaminergic system.
|anti-inflamatory in mice
|Linalool inhibits cigarette smoke-induced lung inflammation by inhibiting NF-kappa-B activation.
|In conclusion, our results demonstrated that linalool protected against CS-induced lung inflammation through inhibiting CS-induced NF-kappa-B activation.
|alzheimers in mice via experiment
|Linalool reverses neuropathological and behavioral impairments in old triple transgenic Alzheimer's mice.
Ingestion Method: 25mg/kg
Together, our findings suggest that linalool reverses the histopathological hallmarks of AD and restores cognitive and emotional functions via an anti-inflammatory effect. Thus, linalool may be an AD prevention candidate for preclinical studies.
|cancer,leukemia,cervical cancer in vitro
|Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs.
|Therefore, this study verified that linalool can arrest the cell cycle of U937 cells at the G0/G1 phase and can arrest the cell cycle of HeLa cells at the G2/M phase.
|sedative in chicks via experiment
|Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.
Ingestion Method: 0.86, 8.6 and 86 mg/chick injection
The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 mg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.
|alzheimers in mice via experiment
|Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice.
|LI could attenuate cognitive deficits induced by Abeta-, and the neuroprotective effect of LI might be mediated by alleviation of apoptosis, oxidative stress depending on activation of Nrf2/HO-1 signaling. We could assume that LI has the potential to be a neuroprotective substance for AD therapy.
|alzheimers in mice via experiment
|The Protective Effect of Lavender Essential Oil and Its Main Component Linalool against the Cognitive Deficits Induced by D-Galactose and Aluminum Trichloride in Mice.
Ingestion Method: 100 mg/kg
Our results revealed that LO (100 mg/kg) or LI (100 mg/kg) significantly protected the cognitive impairments as assessed by the Morris water maze test and step-though test. The mechanisms study demonstrated that LO and LI significantly protected the decreased activity of superoxide dismutase (SOD), glutathione peroxidase (GPX), and protected the increased activity of acetylcholinesterase (AChE) and content of malondialdehyde (MDA).
|anti-bacterial in plants
|Bacteria colonising Penstemon digitalis show volatile and tissue-specific responses to a natural concentration range of the floral volatile linalool.
|We show that response to floral volatiles can be substance and tissue-origin specific. Because linalool could slow growth rate of bacteria across the P. digitalis phyllosphere, floral emission of linalool could play a role in mediating plant-bacteria interactions in this system.
|cardiovascular via review
|The use of terpenes and derivatives as a new perspective for cardiovascular disease treatment: a patent review (2008-2018).
|Several studies have shown the application of terpenes, such as carvacrol, linalool, and limonene in many pharmaceutical and medicinal fields, including cardiovascular disorders, the leading cause of death worldwide.
|anti-viral in vitro via experiment
|Chemical Constituents of Essential Oils Possessing Anti-Influenza A/WS/33 Virus Activity
|This study demonstrated anti-influenza activity in 11 essential oils tested, with marjoram, clary sage and anise essential oils being the most effective at reducing visible cytopathic effects of the A/WS/33 virus. All 3 oils contained linalool, suggesting that this may have anti-influenza activity. Further investigation is needed to characterize the antiviral activity of linalool against influenza A/WS/33 virus.
|anti-bacterial in vitro via experiment
|Yields, chemical composition, and antimicrobial activity of two Algerian essential oils against 40 avian multidrug-resistant Escherichia coli strains.
|In aviculture, these results seem to be very promising in the case where we think about the replacement of antibiotics by EOs, in vivo studies would be very interesting to confirm or invalidate this hypothesis.