|cancer,breast cancer in vitro via experiment
|Anti-invasive effect of Beta-myrcene, a component of the essential oil from Pinus koraiensis cones, in metastatic MDA-MB-231 human breast cancer cells
|Pretreatment with beta--myrcene suppressed TNFalpha--induced phosphorylation of inhibitor of kappa-B kinase and NF-kappa-B as well as matrix metalloproteinase-9 (MMP-9) gene expression in a dose-dependent fashion. Furthermore, beta--myrcene inhibited TNFalpha--induced invasion of MDA-MB-231 cells as determined by three-dimensional spheroid invasion assays.
|anxiety in humans via experiment (n=5)
|Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects.
|These results suggest that the brain wave activity and ANS are affected by the inhalation of the EO of Cannabis sativasuggesting a neuromodular activity in cases of stress, depression, and anxiety.
|pain,headache in humans via survey (n=2032)
|Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort
|Positive Hybrid strains were preferred in ID Migraine(TM), headache, and most pain groups, with OG Shark, a high THC (delta-9-tetrahydrocannabinol)/THCA (tetrahydrocannabinolic acid), low CBD (cannabidiol)/CBDA (cannabidiolic acid), strain with predominant terpenes beta--caryophyllene and beta--myrcene, most preferred in the headache and ID Migraine(TM) groups
|anxiety,sedative in mice via experiment
|Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown
Ingestion Method: 100 and 200 mg/kg
Our study showed that citral, limonene and myrcene presented sedative as well as motor relaxant effects.
|anti-inflamatory in mice
|Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species.
|The oils, when administered orally, were able to inhibit the LPS-induced inflammation including cell migration; with a similar effect being observed for pure limonene.
|pain in rats
|Myrcene mimics the peripheral analgesic activity of lemongrass tea
|Oral administration of an infusion of lemongrass (Cymbopogon citratus) fresh leaves to rats produced a dose-dependent analgesia for the hyperalgesia induced by subplantar injections of either carrageenin or prostaglandin E2, but did not affect that induced by dibutyryl cyclic AMP
|anti-oxidant in vitro
|Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells
Ingestion Method: 0.05-1.5 mg/plate and 0.01-1.0 microg/ml
The results indicate that linalool, eucalyptol and myrcene have substantial protective effect against oxidant induced genotoxicity, which is predominately mediated by their radical scavenging activity.
|pain in mice via experiment
|Effect of myrcene on nociception in mice.
Ingestion Method: 10 and 20 mg kg-1 (i.p.) or at 20 and 40 mg kg-1 (s.c.)
The results suggest that myrcene is capable of inducing antinociception in mice, probably mediated by alpha 2-adrenoceptor stimulated release of endogenous opioids.
|anti-oxidant in mice via experiment (n=40)
|Neuroprotective effects of Beta-myrcene following global cerebral ischemia/reperfusion-mediated oxidative and neuronal damage in a C57BL/J6 mouse
Ingestion Method: 200 mg/kg
However, MYR treatment protected against the oxidative effects of I/R by inducing significant increases in GSH, GPx, and SOD and a significant decrease in the formation of TBARS. Additionally, cerebral I/R increased the incidence of histopathological damage and apoptosis in brain tissue, but these neurodegenerative effects were eliminated by MYR treatment.
|arthritis,anti-inflamatory in vitro
|Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis
|These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation.
|anti-bacterial in vitro via experiment
|The anti-bacterial Effects of Myrcene on Staphylococcus aureus and Its Role in the Essential Oil of the Tea Tree (Melaleuca alternifolia)
|Myrcene acts as an antibacterial agent against S. aureus and is an important contributor to the antibacterial activity of TTO.