Cannabis and Nabilone
Browse the latest research linking medical marijuana / medicinal cannabis and Nabilone (a cannabinoid (synthetic))

Nabilone, sold under the brand name Cesamet among others, is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. [Wikipedia]
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Compounds Topics Title Date
Nabilone chemotherapy,nausea in humans via trial (n=34) Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. Nov 1983
Fewer subjects vomited with nabilone (P = 0.05) and the number of vomiting episodes was lower (P less than 0.05); no patients on nabilone required additional parenteral anti-emetic. More patients preferred nabilone for anti-emetic control (P less than 0.005).
Nabilone,Dronabinol cud in humans via placebo trial (n=14) Subjective, cognitive, and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers Jan 2012
Ingestion Method: nabilone (2, 4, 6, 8 mg), dronabinol (10, 20 mg)
Nabilone (4, 6, 8 mg) and dronabinol (10, 20 mg) increased ratings of feeling a good effect, a strong effect, and/or `high' relative to placebo; nabilone had a slower onset of peak subjective effects than dronabinol. Nabilone (6, 8 mg) modestly lowered psychomotor speed relative to placebo and dronabinol.
Nabilone fibromyalgia in humans via placebo trial (n=40) Nabilone for the treatment of pain in fibromyalgia. Feb 2008
Positive  There were significant decreases in the VAS (-2.04, P < .02), FIQ (-12.07, P < .02), and anxiety (-1.67, P < .02) in the nabilone treated group at 4 weeks. There were no significant improvements in the placebo group. The treatment group experienced more side effects per person at 2 and 4 weeks (1.58, P < .02 and 1.54, P < .05), respectively. Nabilone appears to be a beneficial, well-tolerated treatment option for fibromyalgia patients, with significant benefits in pain relief and functional improvement.
Nabilone sedative in humans via trial (n=29/31) The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Feb 2010
Ingestion Method: 0.5-1.0 mg before bedtime
Positive  Nabilone is effective in improving sleep in patients with FM and is well tolerated. Low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline. Longer trials are needed to determine the duration of effect and to characterize long-term safety.
Nabilone pain via review Nabilone for the Management of Pain. Mar 2016
Eight randomized controlled trials, two prospective cohort trials, and one retrospective chart review were retrieved. Cancer pain, chronic noncancer pain, neuropathic pain, fibromyalgia, and pain associated with spasticity were the pain conditions evaluated. Nabilone was most commonly used as adjunctive therapy and led to small but significant reductions in pain.
Nabilone appetite boost,lung cancer in humans via placebo trial (n=65) The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial. Sep 2018
Ingestion Method: 0.5 mg/2 weeks followed by 1.0 mg/6 weeks
Positive  Nabilone increased their caloric intake (342-kcal) and had a significantly higher intake of carbohydrates (64 g) compared to patients receiving placebo (p = 0.040). Quality of life also showed significant improvements in patients in the experimental arm of the trial, particularly in role functioning (p = 0.030), emotional functioning (p = 0.018), social functioning (p = 0.036), pain (p = 0.06), and insomnia (p = 0.020).
Nabilone chemotherapy,nausea in humans via trial (n=24) A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. Aug 1985
Nabilone was significantly superior to prochlorperazine in the reduction of vomiting episodes. Side effects, mainly vertigo, were evident in nearly half of the patients after nabilone, and three patients were withdrawn from the study due to decreased coordination and hallucinations after nabilone.
Nabilone chemotherapy,nausea in humans via trial (n=30) Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. Jun 1987
Positive  On completion of the trial, 66% of the children stated that they preferred nabilone, 17% preferred prochlorperazine, and 17% had no preference (P = .015, chi 2 test).
Nabilone chemotherapy,nausea A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy. Dec 1982