|anti-viral,anti-bacterial in vitro
|Sensitization of Staphylococcus aureus and Escherichia coli to Antibiotics by the Sesquiterpenoids Nerolidol, Farnesol, Bisabolol, and Apritone
|Our results suggest a general role for the use of sesquiterpenoid compounds as enhancers of nonspecific bacterial permeability to antibiotics and antimicrobials.
|anxiety in mice via placebo trial
|Assessment of anxiolytic effect of nerolidol in mice
Ingestion Method: 12.5, 25, and 50 mg/kg
Our findings indicated that nerolidol exerts an anxiolytic effect without altering the motor coordination.
|anti-inflamatory,parkinsons,neuroprotective in mice
|Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone
|Our findings are the first to show that the neuroprotective effect of nerolidol is mediated through its anti-oxidant and anti-inflammatory activities, which strongly supports its therapeutic potential for the treatment of PD.
|anti-fungal in pigs
|Antifungal effect of eugenol and nerolidol against Microsporum gypseum in a guinea pig model.
Ingestion Method: 0.5-2% topical
Taken together, these results suggest that eugenol and nerolidol could apply supplementary antifungal agents.
|sedative,anti-oxidant in mice via experiment
|anti-oxidant effects of nerolidol in mice hippocampus after open field test.
Ingestion Method: 25, 50 and 75 mg/kg i.p.
Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.
|cancer in mice
|Antitumor Properties of the leaf essential oil of Zornia brasiliensis.
|In conclusion, the leaf essential oil of Z. brasiliensis presents trans-nerolidol, germacrene D, trans-caryophyllene, alpha--humulene, and farnesene as major constituents and is able to inhibit cell proliferation in cultures as well as in tumor growth in mice.
|anti-inflamatory in rats via experiment
|Chemical composition, anti-nociceptive and anti-inflammatory activities of essential oil of Bougainvillea glabra
Ingestion Method: 100-200mg/kg
Positive The anti-nociceptive property of the essential oil was statistically significant p < 0.001 at all doses of when compared to the control while exhibiting an activity in tandem with the standard drug. For the 1st and 2nd h, at doses of 100 and 200 mg/kg, the anti-inflammatory activity was statistically very significant (p < 0.001)