|O-1602,Abn-CBD||diabetes in mice via experiment||G-protein coupled receptor 55 agonists increase insulin secretion through inositol trisphosphate-mediated calcium release in pancreatic beta--cells||Apr 2019|
Action Pathway: GPR55|
Our results demonstrated that O-1602 and Abn-CBD increased glucose-induced insulin secretion in MIN6 cells, which was abolished by a PLC inhibitor, U73122.
|O-1602||gvhd in vitro||A CB2-Selective Cannabinoid Suppresses T-cell Activities and Increases Tregs and IL-10||May 2015|
|These data support the potential of CB2-selective agonists as useful therapeutic agents to prolong graft survival in transplant patients, and strengthens their potential as a new class of immunosuppressive agents with broader applicability.|