| Compounds | Topics | Title | Date |
|---|---|---|---|
| Pinene | anti-viral in vitro | Comparative anti-infectious bronchitis virus (IBV) activity of (-)-pinene: effect on nucleocapsid (N) protein. | Jan 2011 |
| Results presented here may suggest that (-)-alpha--pinene and (-)-beta--pinene possess anti-IBV properties, and therefore are a potential source of anti-IBV ingredients for the pharmaceutical industry. | |||
| Pinene | cancer in vitro | alpha--pinene regulates miR-221 and induces G2/M phase cell cycle arrest in human hepatocellular carcinoma cells | Dec 2018 |
| Additionally, alpha--pinene was found to trigger oxidative stress and induce apoptosis of HepG2 cells. alpha--pinene, therefore, represents a potential chemotherapeutic compound for the treatment of HCC. | |||
| Pinene,Terpineol,Linalool | anti-fungal in vitro | Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. | 2003 |
| All tea tree oil components, except beta-myrcene, had antifungal activity. The lack of activity reported for some components by microdilution may be due to these components becoming absorbed into the polystyrene of the microtitre tray. | |||
| Pinene | alzheimers,parkinsons in vitro | Inhibition of Acetylcholinesterase Activity by Bicyclic Monoterpenoids | Feb 2005 |
| alpha-pinene and (+)-3-carene were potent inhibitors of AChE. | |||
| Humulene,Pinene,Caryophyllene | anti-bacterial in vitro | Composition and anti-bacterial activity of Abies balsamea essential oil. | May 2006 |
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Ingestion Method: essential oil of Abies balsamea (balsam fir) However, three constituents of the essential oil were active against S. aureus: alpha-pinene, beta-caryophyllene (0.4%) and alpha-humulene (0.2%) with MIC values of 13.6 microg/mL, 5.1 microg/mL and 2.6 microg/mL, respectively. | |||
| Pinene,Terpineol | memory in vitro | Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils. | Apr 2009 |
| Among the essential oil components, five components, namely, 1,8-cineole, alpha--pinene, eugenol, alpha--terpineol, and terpinen-4-ol, showed AChE inhibitory activity, with IC(50) values of 0.015, 0.022, 0.48, 1.3, and 3.2 mg/mL, respectively. | |||
| Phellandrene,Terpinolene,Cymene,Pinene | cancer, anti-inflamatory,cancer,breast cancer in vitro | Chemical composition, antimicrobial, and cytotoxicity studies on S. erianthum and S. macranthum essential oils | Apr 2012 |
| The Solanum essential oils possess strong antimicrobial activity in addition to the potent cytotoxic potential of S. erianthum leaf oil against Hs 578T and PC-3 cells. | |||
| Linalool,Pinene | depression in mice via experiment | antidepressant activity of Litsea glaucescens essential oil: Identification of Beta-pinene and linalool as active principles | Sept 2012 |
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Ingestion Method: 100 and 300 mg/Kg. L. glaucescens essential oil showed antidepressant activity, beta--pinene and linalool were identified as its active principles. These results support the use of L. glaucescens in Mexican Traditional Medicine for the treatment of sadness. | |||
| Pinene | cancer,pancreatic cancer in mice via experiment | Protective effects of alpha-pinene in mice with cerulein-induced acute pancreatitis | Oct 2012 |
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Ingestion Method: intraperitoneal Intraperitoneal administration of alpha-pinene reduced the pancreatic weight (PW) to body weight (BW) ratio and the serum levels of amylase and lipase. Alpha-pinene treatment also reduced histological damage and myeloperoxidase activity in the pancreas and lungs. | |||
| Pinene | cancer in vitro | Inhibitory effects of alpha--pinene on hepatoma carcinoma cell proliferation. | 2014 |
| Further experiments showed that alpha--pinene inhibited BEL-7402 cells by arresting cell growth in the G2/M phase of the cell cycle, downregulating Cdc25C mRNA and protein expression, and reducing cycle dependence on kinase 1(CDK1) activity. | |||
| Terpinene,Pinene | anti-inflamatory in vitro | Chemical composition and anti-inflammation activity of essential oils from Citrus unshiu flower. | May 2014 |
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Ingestion Method: essential oils from Citrus unshiu flower The results indicate that the CEO is an effective inhibitor of LPS-induced NO and PGE2 production in RAW 264.7 cells. Additionally, CEO was shown to suppress the production of inflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6. Based on these results, CEO may be considered a potential anti-inflammatory candidate with human health benefits. | |||
| Linalool,Pinene | depression in mice | Linalool and Beta-pinene exert their antidepressant-like activity through the monoaminergic pathway. | May 2015 |
| Our results indicate that linalool and beta--pinene produce an antidepressant-like effect through interaction with the monoaminergic system. | |||
| Pinene | cancer in vitro | Anti-tumor effect of Alpha-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest. | Mar 2015 |
| The results show that liver cancer cell growth was inhibited obviously with inhibitory rate of 79.3% in vitro and 69.1% in vivo, Chk1 and Chk2 levels were upregulated, CyclinB, CDC25 and CDK1 levels were downregulated. | |||
| Pinene | cancer in rats | Antioxidative, anticancer and genotoxic properties of Alpha-pinene on N2a neuroblastoma cells | Aug 2013 |
| Overall our results suggest that alpha--pinene is of a limited therapeutic use as an anticancer agent. | |||
| Pinene,Eugenol | anti-bacterial in vitro via experiment | Inhibitory effect of Beta-pinene, Alpha-pinene and eugenol on the growth of potential infectious endocarditis causing Gram-positive bacteria | Mar 2007 |
| Positive The assayed phytochemicals presented interesting antimicrobial potential noted by low MIC values. MIC values oscillated between 2.5 (eugenol x S. pneumoniae ATCC 11773) to 40 mL/mL (beta-pinene x S. epidermidis ATCC 12228) | |||