| Compounds | Topics | Title | Date |
|---|---|---|---|
| Rimonabant | safety via review | Rimonabant: From RIO to Ban | Jul 2011 |
| The CB1 receptor antagonist Rimonabant entered the European mass market on the back of several trials showing weight loss benefits alongside improvements in numerous other elements of the metabolic syndrome. However, the drug was quickly withdrawn due to the emergence of significant side effects--notably severe mood disorders | |||
| Rimonabant | weight loss in humans via placebo trial | Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. | Apr 2005 |
|
Ingestion Method: 5, 25mg/day CB1 blockade with rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and improvement in cardiovascular risk factors. | |||
| Rimonabant | weight loss in humans via placebo trial (n=1036) | Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. | Nov 2005 |
| Positive Selective CB1-receptor blockade with rimonabant significantly reduces body weight and waist circumference and improves the profile of several metabolic risk factors in high-risk patients who are overweight or obese and have an atherogenic dyslipidemia. | |||
| Rimonabant | weight loss in humans via placebo trial (n=3045) | Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. | Mar 2006 |
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Ingestion Method: 20mg/day Neutral In this multicenter trial, treatment with 20 mg/d of rimonabant plus diet for 2 years promoted modest but sustained reductions in weight and waist circumference and favorable changes in cardiometabolic risk factors. However, the trial was limited by a high drop-out rate and longer-term effects of the drug require further study. | |||
| Rimonabant | weight loss,diabetes in humans via placebo trial (n=1047) | Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. | Nov 2006 |
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Ingestion Method: 5, 25mg/day Positive These data indicate that 20 mg/day rimonabant, in combination with diet and exercise, can produce a clinically meaningful reduction in bodyweight and improve HbA1c and a number of cardiovascular and metabolic risk factors in overweight or obese patients with type 2 diabetes inadequately controlled by metformin or sulphonylureas. | |||
| Rimonabant | safety via review | Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. | Nov 2007 |
| Negative Our findings suggest that 20 mg per day rimonabant increases the risk of psychiatric adverse events--ie, depressed mood disorders and anxiety-despite depressed mood being an exclusion criterion in these trials. Taken together with the recent US Food and Drug Administration finding of increased risk of suicide during treatment with rimonabant, we recommend increased alertness by physicians to these potentially severe psychiatric adverse reactions. | |||
| Rimonabant | weight loss in humans via placebo trial (n=839) | Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial. | Apr 2008 |
| Negative After 18 months of treatment, the study failed to show an effect for rimonabant on disease progression for the primary end point (PAV) but showed a favorable effect on the secondary end point (TAV). | |||
| Rimonabant | cholesterol,liver in humans via placebo trial (n=803) | Effect of rimonabant on the high-triglyceride/ low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial. | Mar 2009 |
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Ingestion Method: 20mg/day In abdominally obese patients with atherogenic dyslipidemia, rimonabant 20 mg significantly improved multiple cardiometabolic risk markers and induced significant reductions in both intraabdominal and liver fat. | |||
| Rimonabant | diabetes in humans via placebo trial (n=368) | Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: the ARPEGGIO trial. | Mar 2010 |
| Positive Rimonabant significantly reduced baseline A1C versus placebo (-0.89 vs. -0.24%; P < 0.0001), and significantly greater improvements were observed in cardiometabolic risk factors. More rimonabant patients achieved >10% reduction in mean total daily insulin dose versus placebo (P = 0.0012), and fewer required rescue medication (P < 0.0001). Hypoglycemia, nausea, dizziness, anxiety, and depression were more frequent with rimonabant. | |||
| Rimonabant | safety via review | An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity. | Feb 2011 |
| Negative Rimonabant is effective in reducing weight in the obese but may lead to intolerable adverse effects most notably psychiatric effects, which make it unsuitable for routine use. However, the drug provides useful proof of principle for this approach to weight loss. | |||