Tetrahydrocannabinol
The principal psychoactive constituent of cannabis
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Uses Title Date
multiple sclerosis
spasticity
pain
Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial Jul 2012
multiple sclerosis
spasticity
Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Aug 2004
pain
Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study July 2018
pain
headache
Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort May 2018
cancer
pancreatic cancer
Potential Use of Cannabinoids for the Treatment of Pancreatic Cancer. Jan 2019
migraine
headache
pain
Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science. Jul 2018
addiction
cocaine
Cannabinoid CB1 receptors mediate the effects of corticotropin?releasing factor on the reinstatement of cocaine seeking and expression of cocaine?induced behavioural sensitization Apr 2012
addiction
heroin
Differential effect of opioid and cannabinoid receptor blockade on heroin?seeking reinstatement and cannabinoid substitution in heroin?abstinent rats Apr 2011
anti-rejection
Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model. Sep 2011
anti-rejection
d9-Tetrahydrocannabinol attenuates allogeneic host-versus-graft response and delays skin graft rejection through activation of cannabinoid receptor 1 and induction of myeloid-derived suppressor cells. Sep 2015
sexual dysfunction
Endocannabinoid system in sexual motivational processes: Is it a novel therapeutic horizon? Jan 2017
sexual dysfunction
Marijuana smoking and markers of testicular function among men from a fertility centre Feb 2019
pain
Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain Feb 2010
diabetes
Decreased prevalence of diabetes in marijuana users: cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) III Feb 2012
pain
Medical Cannabis for Older Patients Nov 2018
adhd
ptsd
Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder Jun 2009
adhd
Cannabinoids in attention-deficit/hyperactivity disorder: A randomised-controlled trial. Aug 2017
diabetes
Cannabis Smoking and Diabetes Mellitus: Results from Meta-Analysis with Eight Independent Replication Samples Jun 2016
diabetes
neuropathy
Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress. Dec 2009
diabetes
neuropathy
Randomized placebo-controlled double-blind clinical trial of cannabis-based medicinal product (Sativex) in painful diabetic neuropathy: depression is a major confounding factor. Oct 2009
addiction
opioid
Emerging Evidence for Cannabis' Role in Opioid Use Disorder Sept 2018
addiction
opioid
Low dose combination of morphine and ?9-tetrahydrocannabinol circumvents antinociceptive tolerance and apparent desensitization of receptors Oct 2008
addiction
opioid
Repeated Cannabinoid Injections into the Rat Periaqueductal Gray Enhances Subsequent Morphine Antinociception Aug 2008
addiction
opioid
Attenuation of precipitated abstinence in methadone-dependent rats by delta 9-THC Jan 1975
addiction
opioid
Endocannabinoid system and opioid addiction: behavioural aspects. Jun 2005
hiv
pain
Cannabis Use in HIV for Pain and Other Medical Symptoms Apr 2005
pain
Amygdala activity contributes to the dissociative effect of cannabis on pain perception. Jan 2013
alzheimers
A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology Oct 2008
herpes
Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro Sep 2004
cancer
Appraising the entourage effect: Antitumor action of a pure cannabinoid versus a botanical drug preparation in preclinical models of breast cancer. Nov 2018
ptsd
The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review of the Current Literature May 2015
ptsd
Tetrahydrocannabinol alone and combined with cannabidiol mitigate fear memory through reconsolidation disruption. Jun 2015
appetite boost
A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. Nov 2011