Cannabis and Terpinolene
Browse the latest research linking medical marijuana / medicinal cannabis and Delta-Terpinene (Terpinolene) (a monoterpene)

Boiling/Vape Point: 186℃
Flavors: Woody
Also in: Tea Tree, Conifers, apple, sage, cumin, rosemary, lilac
Terpinolene is the terpene partly responsible for the woody, piney smell cannabis can often have. [Wikipedia]
Click on a study title below to open a new tab with full article, or click on a compound to see it's full list of research.
Compounds Topics Title Date
Terpinolene cancer in vitro Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells Nov 2011
Action Pathway: AKT1
Terpinolene markedly reduced the protein expression of AKT1; however, linalool or carnosol did not downregulate it.
Terpinolene anti-oxidant in vitro The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL. Jun 2005
Ingestion Method: essential oil of Pinus mugo
The essential oil of Pinus mugo and the contained monoterpene terpinolene effectively prevent low-density lipoprotein (LDL)-oxidation
Terpinolene sedative in mice via experiment Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. Jan 2013
Ingestion Method: inhaled
Elongation of sleeping time induced by pentobarbital was further elongated by the inhalation of terpinolene, but not by that of 1-octen-3-ol. It is indicated that terpinolene is a potent suppressor of the central nervous system.
Phellandrene,Terpinolene,Cymene,Pinene cancer, anti-inflamatory,cancer,breast cancer in vitro Chemical composition, antimicrobial, and cytotoxicity studies on S. erianthum and S. macranthum essential oils Apr 2012
The Solanum essential oils possess strong antimicrobial activity in addition to the potent cytotoxic potential of S. erianthum leaf oil against Hs 578T and PC-3 cells.
Terpinolene anti-oxidant,cancer in vitro Anticancer and anti-oxidant properties of terpinolene in rat brain cells. Sept 2013
Ingestion Method: 50-100mg/L
Our findings clearly demonstrate that TPO is a potent antiproliferative agent for brain tumour cells and may have potential as an anticancer agent, which needs to be further studied.
Terpinolene anti-oxidant in vitro Genotoxic and oxidative damage potentials in human lymphocytes after exposure to terpinolene in vitro. May 2015
Again, TPO (at 10, 25, 50 and 75 mg/L) treatment caused statistically important (p < 0.05) increases of TAC levels in human lymphocytes without changing TOS levels. In conclusion, TPO can be a new resource of therapeutics as recognized in this study with its non-genotoxic and antioxidant features.