|Terpinolene||cancer in vitro||Terpinolene, a component of herbal sage, downregulates AKT1 expression in K562 cells||Nov 2011|
Action Pathway: AKT1|
Terpinolene markedly reduced the protein expression of AKT1; however, linalool or carnosol did not downregulate it.
|Terpinolene||anti-oxidant in vitro||The monoterpene terpinolene from the oil of Pinus mugo L. in concert with alpha-tocopherol and beta-carotene effectively prevents oxidation of LDL.||Jun 2005|
Ingestion Method: essential oil of Pinus mugo|
The essential oil of Pinus mugo and the contained monoterpene terpinolene effectively prevent low-density lipoprotein (LDL)-oxidation
|Terpinolene||sedative in mice via experiment||Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds.||Jan 2013|
Ingestion Method: inhaled|
Elongation of sleeping time induced by pentobarbital was further elongated by the inhalation of terpinolene, but not by that of 1-octen-3-ol. It is indicated that terpinolene is a potent suppressor of the central nervous system.
|Phellandrene,Terpinolene,Cymene,Pinene||cancer, anti-inflamatory,cancer,breast cancer in vitro||Chemical composition, antimicrobial, and cytotoxicity studies on S. erianthum and S. macranthum essential oils||Apr 2012|
|The Solanum essential oils possess strong antimicrobial activity in addition to the potent cytotoxic potential of S. erianthum leaf oil against Hs 578T and PC-3 cells.|
|Terpinolene||anti-oxidant,cancer in vitro||Anticancer and anti-oxidant properties of terpinolene in rat brain cells.||Sept 2013|
Ingestion Method: 50-100mg/L|
Our findings clearly demonstrate that TPO is a potent antiproliferative agent for brain tumour cells and may have potential as an anticancer agent, which needs to be further studied.
|Terpinolene||anti-oxidant in vitro||Genotoxic and oxidative damage potentials in human lymphocytes after exposure to terpinolene in vitro.||May 2015|
|Again, TPO (at 10, 25, 50 and 75 mg/L) treatment caused statistically important (p < 0.05) increases of TAC levels in human lymphocytes without changing TOS levels. In conclusion, TPO can be a new resource of therapeutics as recognized in this study with its non-genotoxic and antioxidant features.|