| Compounds | Topics | Title | Date |
|---|---|---|---|
| JWH-133 | pain,arthritis in rats via experiment | Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. | Nov 2013 |
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Action Pathway: CB2 These data provide new clinically relevant evidence that joint damage and spinal CB2 receptor expression are correlated combined with converging pre-clinical evidence that activation of CB2 receptors inhibits centralsensitization and its contribution to the manifestation of chronic OA pain. These findings suggest that targeting CB2 receptors may have therapeutic potential for treating OA pain. | |||
| HU-308 | anti-inflamatory,arthritis in vitro | Expression of cannabinoid receptor 2 and its inhibitory effects on synovial fibroblasts in rheumatoid arthritis | May 2014 |
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Action Pathway: CB2 In RA-FLS, proinflammatory mediators up-regulate the expression of CB2R, which negatively regulates the production of proinflammatory cytokines and MMPs. These data suggest that CB2R may be a potential therapeutic target of RA. | |||
| cannabinoids | pain,arthritis via review | Involvement of the endocannabinoid system in osteoarthritis pain. | Feb 2014 |
| Increasing evidence from preclinical studies supports the interest of the endocannabinoid system as an emerging therapeutic target for osteoarthritis pain. Indeed, pharmacological studies have shown the anti-nociceptive effects of cannabinoids in different rodent models of osteoarthritis, and compelling evidence suggests an active participation of the endocannabinoid system in the pathophysiology of this disease. | |||
| Caryophyllene,Myrcene | arthritis,anti-inflamatory in vitro | Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis | Mar 2015 |
| These data show that myrcene has significant anti-inflammatory and anti-catabolic effects in human chondrocytes and, thus, its ability to halt or, at least, slow down cartilage destruction and osteoarthritis progression warrants further investigation. | |||
| THC | arthritis,ra via review | The endocannabinoid system and its therapeutic implications in rheumatoid arthritis. | May 2015 |
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Action Pathway: CB2 In particular, specific activation of CB2 may relieve RA by inhibiting not only the production of autoantibodies, proinflammatory cytokines, and MMPs, but also bone erosion, immune response mediated by T cells, and the proliferation of FLSs. In this review, we will discuss the possible functions of the endocannabinoid system in the modulation of RA, which may be a potential target for treatment. | |||
| CBD | arthritis in dogs via placebo trial | Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs. | Jul 2018 |
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Ingestion Method: 2mg/kg CBD oil This pharmacokinetic and clinical study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA. | |||