| Compounds | Topics | Title | Date |
|---|---|---|---|
| ZYN002 | fragilex in humans via trial | A phase 1/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome | Aug 2019 |
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Ingestion Method: titrated from 50 mg to a maximum daily dose of 250 mg ZYN002 was well tolerated and produced clinically meaningful reductions in anxiety and behavioral symptoms in children and adolescents with FXS. These findings support further study of ZYN002 in a randomized, well-controlled trial for the treatment of behavioral symptoms of FXS. | |||
| CBD | fragilex via review | Treatment of Fragile X Syndrome with Cannabidiol: A Case Series Study and Brief Review of the Literature. | Mar 2019 |
| Multiple experimental and clinical models of FXS combine to highlight the therapeutic potential of CBD for management of FXS. All three patients described in the case series exhibited functional benefit following the use of oral CBD+ solutions, including noticeable reductions in social avoidance and anxiety, as well as improvements in sleep, feeding, motor coordination, language skills, anxiety, and sensory processing. Two of the described patients exhibited a reemergence of a number of FXS symptoms following cessation of CBD+ treatment (e.g., anxiety), which then improved again after reintroduction of CBD+ treatment. | |||