Cannabis and gvhd
Browse the latest research linking medical marijuana / medicinal cannabis and gvhd.
Click on a study title below to open a new tab with full article, or click on a compound to see it's full list of research.
Compounds Topics Title Date
THC gvhd in mice via model Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model. Sep 2011
Impaired hematopoiesis seen during GVHD was rescued by treatment with THC. Our results demonstrate for the first time that targeting cannabinoid receptors may constitute a novel treatment modality against acute GVHD.
CBD gvhd in humans via trial (n=48) Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study. Oct 2015
Ingestion Method: 300mg/day
The combination of CBD with standard GVHD prophylaxis is a safe and promising strategy to reduce the incidence of acute GVHD. A randomized double-blind controlled study is warranted.
THC gvhd in mice via experiment d9-Tetrahydrocannabinol attenuates allogeneic host-versus-graft response and delays skin graft rejection through activation of cannabinoid receptor 1 and induction of myeloid-derived suppressor cells. Sep 2015
THC treatment significantly reduced T cell proliferation and activation in draining LNs of the recipient mice and decreased early stage rejection-indicator cytokines, including IL-2 and IFN-g. THC treatment also increased the allogeneic skin graft survival.
O-1602 gvhd in vitro A CB2-Selective Cannabinoid Suppresses T-cell Activities and Increases Tregs and IL-10 May 2015
These data support the potential of CB2-selective agonists as useful therapeutic agents to prolong graft survival in transplant patients, and strengthens their potential as a new class of immunosuppressive agents with broader applicability.