| Compounds | Topics | Title | Date |
|---|---|---|---|
| cannabis | neuropathy,pain,hiv in humans via placebo trial (n=28/34) | Smoked Medicinal Cannabis for Neuropathic Pain in HIV: A Randomized, Crossover Clinical Trial | Aug 2008 |
|
Ingestion Method: Titration was started at 4% THC or placebo and adjusted incrementally downwards (to 2 or 1%) if side effects were intolerable, or upwards (to 6 or 8%) if pain relief was incomplete Positive Pain reduction was significantly greater with cannabis compared to placebo (median difference in pain reduction = 3.3 DDS points; effect size = 0.60; p = 0.016, all completers included; Figure 4). The results were consistent for the ITT analysis (p = 0.020), and for the comparison based on the first week of treatment alone (median change in DDS pain = -4.1 and 0.1 for the cannabis and placebo arms, p = 0.029). There were no evident sequence effects: the degree of pain relief achieved with active cannabis did not differ significantly according to whether it was administered during the first or the second treatment week (mean reduction in DDS points, 4.1 vs 0.96; p = 0.13). | |||
| cannabis | hiv,pain,appetite boost in humans via survey (n=523) | Cannabis Use in HIV for Pain and Other Medical Symptoms | Apr 2005 |
| Positive Symptom control using cannabis is widespread in HIV outpatients. A large number of patients reported that cannabis improved symptom control. | |||
| cannabis | pain,hiv in humans via placebo trial (n=50) | Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. | Feb 2007 |
|
Ingestion Method: 3.56% THC cigarettes Positive Smoked cannabis reduced daily pain by 34% (median reduction; IQR = -71, -16) vs 17% (IQR = -29, 8) with placebo (p = 0.03). Greater than 30% reduction in pain was reported by 52% in the cannabis group and by 24% in the placebo group (p = 0.04). The first cannabis cigarette reduced chronic pain by a median of 72% vs 15% with placebo (p < 0.001) | |||
| cannabinoids | pain,spasticity,hiv,sedative in humans via review | Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. | Jun 2015 |
| Positive Most trials showed improvement in symptoms associated with cannabinoids but these associations did not reach statistical significance in all trials. Compared with placebo, cannabinoids were associated with a greater average number of patients showing a complete nausea and vomiting response (47% vs 20%; odds ratio [OR], 3.82 [95% CI, 1.55-9.42]; 3 trials), reduction in pain (37% vs 31%; OR, 1.41 [95% CI, 0.99-2.00]; 8 trials), a greater average reduction in numerical rating scale pain assessment | |||
| cannabis | hiv in humans | Effect of Cannabis Use on HIV DNA during Suppressive ART. | May 2019 |
| Positive Cannabis use is frequent among people living with HIV and is associated with reduced systemic inflammation. We observed a faster HIV DNA decay during antiretroviral therapy among cannabis users, compared to no drug use. | |||
| Dronabinol | appetite boost,hiv in humans via trial (n=139) | Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. | Feb 1995 |
| Positive Dronabinol was found to be safe and effective for anorexia associated with weight loss in patients with AIDS. | |||