|anti-inflamatory,ibd in mice via experiment
|Beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARg pathway
Ingestion Method: 12.5, 25, or 50 mg/kg, p.o.
Action Pathway: CB2,PPARg
These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARg pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease.
|ibd,anti-inflamatory in mice
|An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse
|In conclusion, CBD BDS, given after the inflammatory insult, attenuates injury and motility in intestinal models of inflammation. These findings sustain the rationale of combining CBD with other minor Cannabis constituents and support the clinical development of CBD BDS for IBD treatment.
|ibd,colon cancer in vitro
|Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer
|There is still a wide gap between preclinical evidence and the role of the ECS in human GI diseases. So far, little evidence exists whether cannabinoids are beneficial in human IBD and CRC, as large clinical trials are still missing.
|ibd,crohns in humans via review
|Cannabis, Cannabinoids, and the Endocannabinoid System--Is there Therapeutic Potential for Inflammatory Bowel Disease?
|Positive Research into the distribution and function of the endocannabinoid system in IBD and models of intestinal inflammation is increasing. There is accumulating evidence that enhancing signalling through cannabinoid receptors 1 and 2 has anti-inflammatory potential in the intestine in vivo
|crohns,ibd in humans via placebo trial (n=20)
|Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial.
Ingestion Method: 10mg
Negative In this study of moderately active Crohn's disease, CBD was safe but had no beneficial effects. This could be due to lack of effect of CBD on Crohn's disease, but could also be due to the small dose of CBD, the small number of patients in the study, or the lack of the necessary synergism with other cannabinoids
|ibd in humans via survey (n=99)
|Marijuana Use by Adolescents and Young Adults with Inflammatory Bowel Disease
|Positive Marijuana use by adolescents and young adults with IBD is common and perceived as beneficial.
|ibd in rats
|Cannabinoid-induced relief of hypermotility in a rat model of the irritable bowel syndrome.
|Cannabinoid-2 receptor agonists may be useful in treating intestinal motility disorders.
|ibd in humans via study (n=6002)
|In-hospital outcomes of inflammatory bowel disease in cannabis users: a nationwide propensity-matched analysis in the United States.
|We found a lower frequency of colorectal cancer, parenteral nutrition, anemia but a higher occurrences of active fistulizing disease or intraabdominal abscess formation, lower GI hemorrhage and hypovolemia in the CD cohort with cannabis usage.