| Nabilone |
chemotherapy,nausea
in humans via trial (n=34) |
Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. |
Nov 1983 |
|
Fewer subjects vomited with nabilone (P = 0.05) and the number of vomiting episodes was lower (P less than 0.05); no patients on nabilone required additional parenteral anti-emetic. More patients preferred nabilone for anti-emetic control (P less than 0.005).
|
| cannabinoids |
chemotherapy,nausea
via review |
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. |
Jun 2001 |
|
Cannabinoids were more effective antiemetics than prochlorperazine, metoclopramide, chlorpromazine, thiethylperazine, haloperidol, domperidone, or alizapride: relative risk 1.38 (95% confidence interval 1.18 to 1.62), number needed to treat 6 for complete control of nausea; 1.28 (1.08 to 1.51), NNT 8 for complete control of vomiting.
|
| THC,WIN55 |
nausea
in shrew |
Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew |
Jun 2007 |
|
Radiation-induced emesis (10 Gy) was blocked in a dose-dependent manner by the CB1/CB2-receptor agonists with the following ID50 potency order: CP55,940 (0.11 (0.09-0.12) mg/kg)>WIN55,212,2 (3.65 (3.15-4.23) mg/kg)=Delta8-THC (4.36 (3.05-6.22) mg/kg)>Delta9-THC (6.76 (5.22-8.75) mg/kg).
|
| cannabinoids |
chemotherapy,nausea
via review |
Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. |
Nov 2015 |
|
Cannabis-based medications may be useful for treating refractory chemotherapy-induced nausea and vomiting. However, methodological limitations of the trials limit our conclusions and further research reflecting current chemotherapy regimens and newer anti-emetic drugs is likely to modify these conclusions.
|
| Nabilone |
chemotherapy,nausea
in humans via trial (n=24) |
A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. |
Aug 1985 |
|
Nabilone was significantly superior to prochlorperazine in the reduction of vomiting episodes. Side effects, mainly vertigo, were evident in nearly half of the patients after nabilone, and three patients were withdrawn from the study due to decreased coordination and hallucinations after nabilone.
|
| Nabilone |
chemotherapy,nausea
in humans via trial (n=30) |
Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. |
Jun 1987 |
|
Positive
On completion of the trial, 66% of the children stated that they preferred nabilone, 17% preferred prochlorperazine, and 17% had no preference (P = .015, chi 2 test).
|
| Nabilone |
chemotherapy,nausea
|
A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy. |
Dec 1982 |