| Compounds | Topics | Title | Date |
|---|---|---|---|
| CBG | hungtingtons disease,neuroprotective in mice via experiment | Neuroprotective Properties of Cannabigerol in Huntingtons Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice | Jan 2015 |
| CBG was extremely active as neuroprotectant in mice intoxicated with 3-nitropropionate (3NP), improving motor deficits and preserving striatal neurons against 3NP toxicity. | |||
| CBD | epilepsy,anti-inflamatory,neuroprotective via review | Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders | May 2014 |
| The antiepileptic mechanisms of CBD are not known, but may include effects on the equilibrative nucleoside transporter; the orphan G-protein-coupled receptor GPR55; the transient receptor potential of melastatin type 8 channel; the 5-HT1a receptor; the alpha-3 and alpha-1 glycine receptors; and the transient receptor potential of ankyrin type 1 channel. CBD has neuroprotective and anti-inflammatory effects. | |||
| Nerolidol | anti-inflamatory,parkinsons,neuroprotective in mice | Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone | Aug 2016 |
| Our findings are the first to show that the neuroprotective effect of nerolidol is mediated through its anti-oxidant and anti-inflammatory activities, which strongly supports its therapeutic potential for the treatment of PD. | |||
| THC | neuroprotective in mice via experiment | Pre- and post-conditioning treatment with an ultra-low dose of delta-9-tetrahydrocannabinol (THC) protects against pentylenetetrazole (PTZ)-induced cognitive damage. | Jun 2011 |
|
Ingestion Method: 0.002 mg/kg We found that a single administration of THC either before or after PTZ abolished the PTZ-induced long-lasting cognitive deficits. | |||
| CBG | neuroprotective,hungtingtons disease in mice | Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice. | Jan 2015 |
| CBG was extremely active as neuroprotectant in mice intoxicated with 3-nitropropionate (3NP), improving motor deficits and preserving striatal neurons against 3NP toxicity. In addition, CBG attenuated the reactive microgliosis and the upregulation of proinflammatory markers induced by 3NP, and improved the levels of antioxidant defenses that were also significantly reduced by 3NP. | |||
| THC | neuroprotective in mice via experiment | A chronic low dose of delta-9-tetrahydrocannabinol (THC) restores cognitive function in old mice. | Jun 2017 |
| THC treatment restored hippocampal gene transcription patterns such that the expression profiles of THC-treated mice aged 12 months closely resembled those of THC-free animals aged 2 months. | |||
| CBD | alzheimers,neuroprotective in vitro via experiment | Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer's Disease. | Mar 2019 |
|
Action Pathway: PPARg However in the presence of the PPARg antagonist GW9662 the neuroprotective effect of CBD was prevented. Our data suggests that this major component of Cannabis sativa, which lacks psychoactivity may have therapeutic potential for the treatment of AD. | |||
| CBD,CBDV | neuroprotective in vitro | Low doses of widely consumed cannabinoids (cannabidiol and cannabidivarin) cause DNA damage and chromosomal aberrations in human-derived cells. | Jan 2019 |
| Negative Both compounds induced DNA damage in single cell gel electrophoresis (SCGE) experiments in a human liver cell line (HepG2) and in buccal-derived cells (TR146) at low levels (>= 0.2 uM). | |||