| Compounds | Topics | Title | Date |
|---|---|---|---|
| cannabis | ptsd in humans via study (n=545) | Interactive effects of PTSD and substance use on suicidal ideation and behavior in military personnel: Increased risk from marijuana use | Sep 2019 |
| The interaction between PTSD symptoms and marijuana use significantly predicted increased PTSD symptoms over time and suicidal behavior. At high, but not low levels of PTSD symptoms, more days using marijuana predicted increased PTSD symptoms over time and the likelihood of suicidal behavior. | |||
| cannabinoids | adhd,ptsd in vitro | Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder | Jun 2009 |
| These observations require replication, however, they suggest that the CNR1 gene may be a risk factor for ADHD and possibly PTSD, and that this gene warrants further investigation for a role in neuropsychiatric disorders. | |||
| cannabis | ptsd via review | The Use of Medicinal Marijuana for Posttraumatic Stress Disorder: A Review of the Current Literature | May 2015 |
| Posttraumatic stress disorder is 1 of the approved conditions for medicinal marijuana in some states. While the literature to date is suggestive of a potential decrease in PTSD symptomatology with the use of medicinal marijuana, there is a notable lack of large-scale trials, making any final conclusions difficult to confirm at this time. | |||
| CBD | ptsd,anxiety,insomnia in humans via case study (n=1) | Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report | Oct 2016 |
|
Ingestion Method: 25mg bedtime, 6mg-12mg spray for anxiety Positive Although studies have demonstrated the calming, anti-inflammatory, and relaxing effects of CBD, clinical data from actual cases is minimal. This case study offers evidence that CBD is effective as a safe alternative treatment to traditional psychiatric medications for reducing anxiety and insomnia. | |||
| CBD | ptsd via review | Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials | Jul 2018 |
| Preclinical studies in different rodent behavioral models have shown that CBD can both facilitate the extinction of aversive memories and block their reconsolidation, possibly through potentialization of the eCB system. These results, combined with the currently available pharmacological treatments for PTSD being limited, necessitated testing CBD use with the same therapeutic purpose in humans as well. | |||
| THC | ptsd in mice | Tetrahydrocannabinol alone and combined with cannabidiol mitigate fear memory through reconsolidation disruption. | Jun 2015 |
|
Ingestion Method: 0.3-10mg/kg, i.p. Action Pathway: CB1 We report that THC (0.3-10mg/kg, i.p.) was able to disrupt the reconsolidation of a contextual fear memory, resulting in reduced conditioned freezing expression for over 22 days. This effect was dependent on activation of cannabinoid type-1 receptors located in prelimbic subregion of the medial prefrontal cortex and on memory retrieval/reactivation. | |||
| cannabis | ptsd via review | Cannabinoids and post-traumatic stress disorder: clinical and preclinical evidence for treatment and prevention. | Oct 2016 |
| Preliminary studies in humans also suggest that treatment with cannabinoids may decrease PTSD symptoms including sleep quality, frequency of nightmares, and hyperarousal. | |||
| CBD | ptsd in humans via trial (n=11) | Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. | Apr 2019 |
| Positive From the total sample of 11 patients, 91% (n = 10) experienced a decrease in PTSD symptom severity, as evidenced by a lower PCL-5 score at 8 weeks than at their initial baseline. The mean total PCL-5 score decreased 28%, from a mean baseline score of 51.82 down to 37.14, after eight consecutive weeks of treatment with CBD. CBD was generally well tolerated, and no patients discontinued treatment due to side effects. | |||
| CBD | ptsd via review | Cannabinoid Regulation of Fear and Anxiety: an Update. | Apr 2019 |
| The findings from the relevant clinical literature are still very preliminary but are nonetheless encouraging. Based on this preclinical evidence, larger-scale placebo-controlled clinical studies are warranted to investigate the effects of cannabidiol in particular as an adjunct to psychological therapy or medication to determine its potential utility for treating anxiety-related disorders in the future. | |||
| cannabis | ptsd in humans via study (n=1107) | Post-traumatic stress and marijuana outcomes: The mediating role of marijuana protective behavioral strategies. | Jul 2019 |
| Taken together, the associations between higher PTSD symptoms and greater experience of CUD symptoms and marijuana-related problems may occur because students use fewer protective measures and thus engage in larger quantity and frequency of marijuana use. | |||
| cannabinoids | ptsd via review | The Effectiveness of Cannabinoids in the Treatment of Posttraumatic Stress Disorder (PTSD): A Systematic Review. | Sep 2019 |
| Most studies to date are small and of low quality, with significant limitations to the study designs precluding any clinical recommendations about its use in routine clinical practice. Evidence that cannabinoids may help reduce global PTSD symptoms, sleep disturbances, and nightmares indicates that future well-controlled, randomized, double-blind clinical trials are highly warranted | |||