Cannabis and sedative
Browse the latest research linking medical marijuana / medicinal cannabis and sedative.
Sleeping aids
Click on a study title below to open a new tab with full article, or click on a compound to see it's full list of research.
Compounds Topics Title Date
cannabis pain,anxiety,sedative,migraine in humans via survey (n=1513) Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep Apr 2019
Positive  In conclusion, a majority of patients reported using less opioids as well as fewer medications to treat anxiety, migraines, and sleep after initiating MC. A smaller portion used less antidepressants or alcohol.
Linalool sedative,pain via review Lavender and the Nervous System Mar 2013
Several animal and human investigations suggest anxiolytic, mood stabilizer, sedative, analgesic, and anticonvulsive and neuroprotective properties for lavender.
Myrcene anxiety,sedative in mice via experiment Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown Nov 2004
Ingestion Method: 100 and 200 mg/kg
Our study showed that citral, limonene and myrcene presented sedative as well as motor relaxant effects.
Linalool sedative in mice Inhaled linalool-induced sedation in mice. Apr 2009
Ingestion Method: 1-3% inhaled
The 1% and 3% linalool increased (p<0.01) pentobarbital sleeping time and reduced (p<0.01) body temperature. The 3% linalool decreased (p<0.01) locomotion. Motor coordination was not affected. Hence, linalool inhaled for 1h seems to induce sedation without significant impairment in motor abilities, a side effect shared by most psycholeptic drugs.
Nabilone sedative in humans via trial (n=29/31) The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. Feb 2010
Ingestion Method: 0.5-1.0 mg before bedtime
Positive  Nabilone is effective in improving sleep in patients with FM and is well tolerated. Low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline. Longer trials are needed to determine the duration of effect and to characterize long-term safety.
Terpinolene sedative in mice via experiment Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. Jan 2013
Ingestion Method: inhaled
Elongation of sleeping time induced by pentobarbital was further elongated by the inhalation of terpinolene, but not by that of 1-octen-3-ol. It is indicated that terpinolene is a potent suppressor of the central nervous system.
Nerolidol sedative,anti-oxidant in mice via experiment anti-oxidant effects of nerolidol in mice hippocampus after open field test. Jul 2016
Ingestion Method: 25, 50 and 75 mg/kg i.p.
Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.
cannabis pain,sedative,anxiety in humans via survey (n=628) Cannabis for therapeutic purposes: patient characteristics, access, and reasons for use. Nov 2013
Positive  Across medical conditions respondents reported using cannabis to effectively address diverse symptoms. Results indicate a substantial disconnect between the therapeutic use of cannabis and research on the risks and benefits of such use; particularly with regard to the anxiolytic and sedative use of cannabis.
cannabinoids pain,spasticity,hiv,sedative in humans via review Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. Jun 2015
Positive  Most trials showed improvement in symptoms associated with cannabinoids but these associations did not reach statistical significance in all trials. Compared with placebo, cannabinoids were associated with a greater average number of patients showing a complete nausea and vomiting response (47% vs 20%; odds ratio [OR], 3.82 [95% CI, 1.55-9.42]; 3 trials), reduction in pain (37% vs 31%; OR, 1.41 [95% CI, 0.99-2.00]; 8 trials), a greater average reduction in numerical rating scale pain assessment
cannabis sedative via survey (n=98) Marijuana use patterns and sleep among community-based young adults Oct 2014
Negative  Covariate adjusted regression analyses revealed mean Pittsburgh Sleep Quality Index and Insomnia Severity Index scores were significantly lower for non-daily users and controls relative to the daily users. When adjusting for depression and anxiety, these unique associations were not significant.
Linalool sedative in chicks via experiment Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks. Oct 2016
Ingestion Method: 0.86, 8.6 and 86 mg/chick injection
The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 mg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.
Geraniol sedative in rats via experiment Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra. Oct 2018
Ingestion Method: 25, 50 and 100 mg/kg intravenous
Positive  The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats.
Terpinene sedative in mice via experiment Enhancement of Pentobarbital-induced Sleep by the Vaporized Essential Oil of Citrus keraji var. kabuchii and its Characteristic Component, y-Terpinene. Aug 2016
Thus, vaporized Kabuchii essential oil and its active component, y-terpinene, have sedative effects comparable with diazepam without inducing motor incoordination, which is a well-known side effect of. diazepam.
cannabis sedative,insomnia in rats via experiment Acute effect of vaporized Cannabis on sleep and electrocortical activity Feb 2019
Ingestion Method: 0 (control), 40, 80 and 200 mg of 11.5% THC Cannabis
Neutral  In conclusion, administration of low doses of THC by vaporization of a specific type of Cannabis produced a small increment of NREM sleep, but only during the light (resting) phase. This was accompanied by subtle modifications of high frequency bands power (during the light phase) and spindle coherence (during the dark phase), which are associated with cognitive processing
THC,CBD sedative in humans via review The use of cannabinoids for sleep: A critical review on clinical trials. May 2019
Positive  Many of the reviewed studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency.
2AG pain,sedative in mice Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Jun 1995
Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature. 2-Ara-Gl also shares the ability of delta 9-THC to inhibit electrically evoked contractions of mouse isolated vasa deferentia; however, it was less potent than delta 9-THC.