|cannabis||pain,anxiety,sedative,migraine in humans via survey (n=1513)||Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep||Apr 2019|
|Positive In conclusion, a majority of patients reported using less opioids as well as fewer medications to treat anxiety, migraines, and sleep after initiating MC. A smaller portion used less antidepressants or alcohol.|
|Linalool||sedative,pain via review||Lavender and the Nervous System||Mar 2013|
|Several animal and human investigations suggest anxiolytic, mood stabilizer, sedative, analgesic, and anticonvulsive and neuroprotective properties for lavender.|
|Myrcene||anxiety,sedative in mice via experiment||Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown||Nov 2004|
Ingestion Method: 100 and 200 mg/kg|
Our study showed that citral, limonene and myrcene presented sedative as well as motor relaxant effects.
|Linalool||sedative in mice||Inhaled linalool-induced sedation in mice.||Apr 2009|
Ingestion Method: 1-3% inhaled|
The 1% and 3% linalool increased (p<0.01) pentobarbital sleeping time and reduced (p<0.01) body temperature. The 3% linalool decreased (p<0.01) locomotion. Motor coordination was not affected. Hence, linalool inhaled for 1h seems to induce sedation without significant impairment in motor abilities, a side effect shared by most psycholeptic drugs.
|Nabilone||sedative in humans via trial (n=29/31)||The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial.||Feb 2010|
Ingestion Method: 0.5-1.0 mg before bedtime|
Positive Nabilone is effective in improving sleep in patients with FM and is well tolerated. Low-dose nabilone given once daily at bedtime may be considered as an alternative to amitriptyline. Longer trials are needed to determine the duration of effect and to characterize long-term safety.
|Terpinolene||sedative in mice via experiment||Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds.||Jan 2013|
Ingestion Method: inhaled|
Elongation of sleeping time induced by pentobarbital was further elongated by the inhalation of terpinolene, but not by that of 1-octen-3-ol. It is indicated that terpinolene is a potent suppressor of the central nervous system.
|Nerolidol||sedative,anti-oxidant in mice via experiment||anti-oxidant effects of nerolidol in mice hippocampus after open field test.||Jul 2016|
Ingestion Method: 25, 50 and 75 mg/kg i.p.|
Nerolidol showed sedative effects in animals subjected to the open field test. Oxidative process plays a crucial role on neuronal pathological consequence, and implies that antioxidant effects could be achieved using this sesquiterpene.
|cannabis||pain,sedative,anxiety in humans via survey (n=628)||Cannabis for therapeutic purposes: patient characteristics, access, and reasons for use.||Nov 2013|
|Positive Across medical conditions respondents reported using cannabis to effectively address diverse symptoms. Results indicate a substantial disconnect between the therapeutic use of cannabis and research on the risks and benefits of such use; particularly with regard to the anxiolytic and sedative use of cannabis.|
|cannabinoids||pain,spasticity,hiv,sedative in humans via review||Cannabinoids for Medical Use: A Systematic Review and Meta-analysis.||Jun 2015|
|Positive Most trials showed improvement in symptoms associated with cannabinoids but these associations did not reach statistical significance in all trials. Compared with placebo, cannabinoids were associated with a greater average number of patients showing a complete nausea and vomiting response (47% vs 20%; odds ratio [OR], 3.82 [95% CI, 1.55-9.42]; 3 trials), reduction in pain (37% vs 31%; OR, 1.41 [95% CI, 0.99-2.00]; 8 trials), a greater average reduction in numerical rating scale pain assessment|
|cannabis||sedative via survey (n=98)||Marijuana use patterns and sleep among community-based young adults||Oct 2014|
|Negative Covariate adjusted regression analyses revealed mean Pittsburgh Sleep Quality Index and Insomnia Severity Index scores were significantly lower for non-daily users and controls relative to the daily users. When adjusting for depression and anxiety, these unique associations were not significant.|
|Linalool||sedative in chicks via experiment||Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.||Oct 2016|
Ingestion Method: 0.86, 8.6 and 86 ?g/chick injection|
The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 ?g doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.
|Geraniol||sedative in rats via experiment||Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra.||Oct 2018|
Ingestion Method: 25, 50 and 100 mg/kg intravenous|
Positive The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats.
|Terpinene||sedative in mice via experiment||Enhancement of Pentobarbital-induced Sleep by the Vaporized Essential Oil of Citrus keraji var. kabuchii and its Characteristic Component, y-Terpinene.||Aug 2016|
|Thus, vaporized Kabuchii essential oil and its active component, y-terpinene, have sedative effects comparable with diazepam without inducing motor incoordination, which is a well-known side effect of. diazepam.|
|cannabis||sedative,insomnia in rats via experiment||Acute effect of vaporized Cannabis on sleep and electrocortical activity||Feb 2019|
Ingestion Method: 0 (control), 40, 80 and 200 mg of 11.5% THC Cannabis|
Neutral In conclusion, administration of low doses of THC by vaporization of a specific type of Cannabis produced a small increment of NREM sleep, but only during the light (resting) phase. This was accompanied by subtle modifications of high frequency bands power (during the light phase) and spindle coherence (during the dark phase), which are associated with cognitive processing
|THC,CBD||sedative in humans via review||The use of cannabinoids for sleep: A critical review on clinical trials.||May 2019|
|Positive Many of the reviewed studies suggested that cannabinoids could improve sleep quality, decrease sleep disturbances, and decrease sleep onset latency.|
|2AG||pain,sedative in mice||Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors.||Jun 1995|
|Upon intravenous administration to mice, 2-Ara-Gl caused the typical tetrad of effects produced by THC: antinociception, immobility, reduction of spontaneous activity, and lowering of the rectal temperature. 2-Ara-Gl also shares the ability of delta 9-THC to inhibit electrically evoked contractions of mouse isolated vasa deferentia; however, it was less potent than delta 9-THC.|