|THC||cancer,blood cancer in vitro||Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.||Jul 2002|
Action Pathway: CB2|
Exposure of murine tumors EL-4, LSA, and P815 to delta-9-tetrahydrocannabinol (THC) in vitro led to a significant reduction in cell viability and an increase in apoptosis.
|THC||cancer,blood cancer in vitro||Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.||Aug 2006|
|The data showed that THC down-regulated Raf-1/mitogen-activated protein kinase/ERK kinase (MEK)/ERK/RSK pathway leading to translocation of Bad to mitochondria. THC also decreased the phosphorylation of Akt.|