| Compounds | Topics | Title | Date |
|---|---|---|---|
| CBD | cancer,glioma in vitro via experiment | Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism | Apr 2005 |
| These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified. | |||
| CBD,THC | cancer,glioma in vitro | Cannabidiol enhances the inhibitory effects of delta-9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival | Jan 2010 |
| Our results suggest that the addition of CBD to delta-9-THC may improve the overall effectiveness of delta-9-THC in the treatment of glioblastoma in cancer patients. | |||
| JWH-133 | cancer,glioma in mice via experiment | Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. | Aug 2001 |
|
Ingestion Method: 50 microg/day Action Pathway: CB2 Experiments carried out with C6 glioma cells in culture evidenced the internalization of the CB(2) but not the CB(1) receptor upon JWH-133 challenge and showed that selective activation of the CB(2) receptor signaled apoptosis via enhanced ceramide synthesis de novo. These results support a therapeutic approach for the treatment of malignant gliomas devoid of psychotropic side effects. | |||
| CBD | cancer,glioma in mice via experiment | Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. | Mar 2004 |
| In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent. | |||
| cannabinoids | cancer,glioma in vitro | Cannabinoid receptors in human astroglial tumors. | Aug 2006 |
| We conclude that cannabinoid therapy of human gliomas targets not only receptors on tumor, but also on other cell types. Therefore, complex and potential side-effects should be considered carefully. | |||
| cannabinoids | cancer,glioma in vitro | Predominant CB2 receptor expression in endothelial cells of glioblastoma in humans. | Jun 2009 |
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Action Pathway: CB2 In glioblastoma endothelial cells, CB1 and CB2 receptors were present in about 38% and 54% of the cells respectively. In comparison to CB1, an elevated CB2 receptor expression was identified in glioblastoma. | |||
| WIN55 | cancer,glioma in vitro | Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. | May 2010 |
| The present results demonstrate opposite changes in CB(1) and CB(2) receptor protein expression in human gliomas. These changes may be of interest for further research about the therapeutic effects of cannabinoids in glial tumors. | |||
| cannabinoids | cancer,glioma via review | Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas. | Jan 2014 |
| Positive In all experimental studies included, cannabinoids exerted antitumoral activity in vitro and/or antitumoral evidence in vivo in several models of tumor cells and tumors. | |||