| Compounds | Topics | Title | Date |
|---|---|---|---|
| CBD | anxiety,sleep in humans via study (n=72) | Cannabidiol in Anxiety and Sleep: A Large Case Series | Jan 2019 |
|
Ingestion Method: 25 mg/d to 175 mg/d Current understanding of the physiology and neurologic pathways points to a benefit with anxiety-related issues. The results of our clinical report support the existing scientific evidence. In our study, we saw no evidence of a safety issue that would limit future studies. In this evaluation, CBD appears to be better tolerated than routine psychiatric medications. | |||
| AM251 | sleep in rats via experiment | AM-251, A Cannabinoid Antagonist, Modifies the Dynamics of Sleep-Wake Cycles in Rats | Jul 2019 |
| AM-251 induced a dose- and time-dependent increase in the number of bouts in active wake (AW), and it decreased this number in all other vigilance states except in passive wake (PW). In contrast, the bout duration in PW compensatory decreased. | |||
| Dronabinol | appetite boost,sleep,cancer in humans via placebo trial (n=47/65) | Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. | Sep 2011 |
| Positive THC-treated patients reported improved (P = 0.026) and enhanced (P < 0.001) chemosensory perception and food 'tasted better' (P = 0.04). Premeal appetite (P = 0.05) and proportion of calories consumed as protein increased compared with placebo (P = 0.008). THC-treated patients reported increased quality of sleep (P = 0.025) and relaxation (P = 0.045). | |||
| cannabis | sleep via review | Cannabis, Cannabinoids, and Sleep: a Review of the Literature. | Apr 2017 |
| Neutral Research on cannabis and sleep is in its infancy and has yielded mixed results. Additional controlled and longitudinal research is critical to advance our understanding of research and clinical implications. | |||
| cannabis | pain,sleep in humans via survey (n=1000) | Use of Cannabis to Relieve Pain and Promote Sleep by Customers at an Adult Use Dispensary. | Jul 2019 |
| Among respondents taking cannabis for pain, 80% reported that it was very or extremely helpful, and most of those taking over-the-counter pain medications (82%) or opioid analgesics (88%) reported reducing or stopping use of those medications. Among respondents taking cannabis for sleep, 84% found it very or extremely helpful, and most of those taking over-the-counter (87%) or prescription sleep aids (83%) reported reducing or stopping use of those medications. | |||
| cannabis | sleep in humans via study (n=311) | Cannabis Expectancies for Sleep. | Jul 2019 |
| Analyses revealed that participants expected cannabis to decrease the incidence of sleep-related problems, including allowing participants to have an earlier bedtime, to fall asleep more quickly, and to have a longer night's sleep. Moreover, expectancies about the influence of cannabis on sleep negatively covaried with cannabis-related problems. | |||
| cannabis | sleep in humans via study (n=1656) | Onset of regular cannabis use and adult sleep duration: Genetic variation and the implications of a predictive relationship | Aug 2019 |
| Earlier age of onset for regular cannabis use was significantly associated with shorter adult sleep duration on both weekdays (beta- = -0.13, 95% CI = [-0.23, -0.04]) and weekends (beta- = -0.18, 95% CI = [-0.27, -0.08]). | |||